FTO‐mediated m6A demethylation regulates IGFBP3 expression and AKT activation through IMP3‐dependent P‐body re‐localisation in lung cancer

FTO‐mediated m6A demethylation regulates IGFBP3 expression and AKT activation through IMP3‐dependent P‐body re‐localisation in lung cancer

Abstract Lung cancer remains one of the leading causes of cancer‐related deaths worldwide, and a growing body of evidence suggests that RNA modifications, including methylation, play a critical role in its progression. In this study, we investigated the role of the RNA demethylase fat mass and obesi...

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Bibliographic Details
Main Authors: Haiyang Wang, Hui Peng, Zhenzhen Zhang, Yilimunuer Abulimiti, Jiayi Hu, Yongxin Zhou, Ping Ji, Dong Li
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Clinical and Translational Medicine
Subjects:
FTO
IGFBP3
lung adenocarcinoma
m6A
P‐bodies
Online Access:https://doi.org/10.1002/ctm2.70392
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