Exploring the active ingredients and potential mechanisms of Pingchan granules in Parkinson’s disease treatment through network pharmacology and transcriptomics

Exploring the active ingredients and potential mechanisms of Pingchan granules in Parkinson’s disease treatment through network pharmacology and transcriptomics

Abstract Parkinson’s disease (PD), the second most prevalent neurodegenerative disorder, poses significant challenges to single-target therapeutic strategies due to its complex etiology. This has driven interest in multi-target approaches, particularly those leveraging natural compounds. Pingchan gr...

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Bibliographic Details
Main Authors: Qiu-Han Xu, Yi-Ling Wang, Cheng Wang, Si-Si Jiang, Bao-Rong Zhang, Jun Tian
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Scientific Reports
Subjects:
Parkinson’s disease
Pingchan granules
Network Pharmacology
Single-cell nuclear sequencing
Molecular dynamics simulation
Mendelian randomization
Online Access:https://doi.org/10.1038/s41598-025-91344-x
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https://doi.org/10.1038/s41598-025-91344-x

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