Mitochondrial fission factor drives an actionable metabolic vulnerability in multiple myeloma

Mitochondrial fission factor drives an actionable metabolic vulnerability in multiple myeloma

Proliferating multiple myeloma (MM) cells in the bone marrow fluctuate across various metabolic states to resist cancer treatments. Herein, we investigate how mitochondrial dynamics, which controls mitochondrial fitness via coordinated fission and fusion events, shapes MM cell metabolism impacting...

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Main Authors: Maria Eugenia Gallo Cantafio, Ilenia Valentino, Roberta Torcasio, Ludovica Ganino, Claudia Veneziano, Pierpaolo Murfone, Maria Mesuraca, Ida Perrotta, Federico Tallarigo, Valter Agosti, Carmela De Marco, Teresa Pasqua, Cesarina Giallongo, Anna Rita Cappello, Marco Fiorillo, Massimo Gentile, Daniele Tibullo, Giuseppe Viglietto, Antonino Neri, Nicola Amodio
Format: Article
Language:English
Published: Ferrata Storti Foundation 2025-05-01
Series:Haematologica
Online Access:https://haematologica.org/article/view/12075
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https://haematologica.org/article/view/12075

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