Effect of cerebrolysin on dopaminergic neurodegeneration of rat with oxidative stress induced by 3-nitropropionic acid
The study tested the hypothesis that cerebrolysin protects the brain from free radicals in rats treated with 3-nitropropionic acid (3-NPA). To address this hypothesis, the levels of dopamine (DA) and some oxidative stress biomarkers were measured after administration of 3-NPA. Young male Fischer rat...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Sciendo
2016-09-01
|
| Series: | Acta Pharmaceutica |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/acph-2016-0027 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832569661115334656 |
|---|---|
| author | Calderón Guzmán David Brizuela Norma Osnaya Ortíz Herrera Maribel Hernández García Ernestina Barragán Mejía Gerardo Juárez Olguín Hugo Valenzuela Peraza Armando Attilus Jonas Labra Ruíz Norma |
| author_facet | Calderón Guzmán David Brizuela Norma Osnaya Ortíz Herrera Maribel Hernández García Ernestina Barragán Mejía Gerardo Juárez Olguín Hugo Valenzuela Peraza Armando Attilus Jonas Labra Ruíz Norma |
| author_sort | Calderón Guzmán David |
| collection | DOAJ |
| description | The study tested the hypothesis that cerebrolysin protects the brain from free radicals in rats treated with 3-nitropropionic acid (3-NPA). To address this hypothesis, the levels of dopamine (DA) and some oxidative stress biomarkers were measured after administration of 3-NPA. Young male Fischer rats were treated for three days with cerebrolysin, 3-NPA or both substances. Their brains were extracted, and DA, lipid peroxidation (LP), glutathione (GSH), calcium, and H2O2 were measured using validated methods. In the cortex, hemispheres and cerebellum/medulla oblongata of the group treated with cerebrolysin and 3-NPA, the levels of DA and LP decreased. In addition, calcium and H2O2 levels decreased in the hemispheres of the same group, while GSH increased in cortex. The increased dopamine metabolism due to the administration of cerebrolysin led to increased formation of radical species and oxidative stress, especially when free radicals were generated by 3-NPA. |
| format | Article |
| id | doaj-art-63eee3e1cb4f4daea4a585667088a4ad |
| institution | Kabale University |
| issn | 1846-9558 |
| language | English |
| publishDate | 2016-09-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Acta Pharmaceutica |
| spelling | doaj-art-63eee3e1cb4f4daea4a585667088a4ad2025-02-02T19:57:23ZengSciendoActa Pharmaceutica1846-95582016-09-0166344344810.1515/acph-2016-0027acph-2016-0027Effect of cerebrolysin on dopaminergic neurodegeneration of rat with oxidative stress induced by 3-nitropropionic acidCalderón Guzmán David0Brizuela Norma Osnaya1Ortíz Herrera Maribel2Hernández García Ernestina3Barragán Mejía Gerardo4Juárez Olguín Hugo5Valenzuela Peraza Armando6Attilus Jonas7Labra Ruíz Norma8Laboratorio de Neurociencias Instituto Nacional de Pediatría (INP) México City, MéxicoLaboratorio de Bacteriología Experimental INP, México City, MéxicoLaboratorio de Bacteriología Experimental INP, México City, MéxicoLaboratorio de Farmacología, INP México City, MéxicoLaboratorio de Neurociencias Instituto Nacional de Pediatría (INP) México City, MéxicoLaboratorio de Farmacología, INP México City, MéxicoLaboratorio de Neurociencias Instituto Nacional de Pediatría (INP) México City, MéxicoLaboratorio de Neurociencias Instituto Nacional de Pediatría (INP) México City, MéxicoLaboratorio de Neurociencias Instituto Nacional de Pediatría (INP) México City, MéxicoThe study tested the hypothesis that cerebrolysin protects the brain from free radicals in rats treated with 3-nitropropionic acid (3-NPA). To address this hypothesis, the levels of dopamine (DA) and some oxidative stress biomarkers were measured after administration of 3-NPA. Young male Fischer rats were treated for three days with cerebrolysin, 3-NPA or both substances. Their brains were extracted, and DA, lipid peroxidation (LP), glutathione (GSH), calcium, and H2O2 were measured using validated methods. In the cortex, hemispheres and cerebellum/medulla oblongata of the group treated with cerebrolysin and 3-NPA, the levels of DA and LP decreased. In addition, calcium and H2O2 levels decreased in the hemispheres of the same group, while GSH increased in cortex. The increased dopamine metabolism due to the administration of cerebrolysin led to increased formation of radical species and oxidative stress, especially when free radicals were generated by 3-NPA.https://doi.org/10.1515/acph-2016-0027cerebrolysindopamine3-nitropropionic acidoxidative stress |
| spellingShingle | Calderón Guzmán David Brizuela Norma Osnaya Ortíz Herrera Maribel Hernández García Ernestina Barragán Mejía Gerardo Juárez Olguín Hugo Valenzuela Peraza Armando Attilus Jonas Labra Ruíz Norma Effect of cerebrolysin on dopaminergic neurodegeneration of rat with oxidative stress induced by 3-nitropropionic acid Acta Pharmaceutica cerebrolysin dopamine 3-nitropropionic acid oxidative stress |
| title | Effect of cerebrolysin on dopaminergic neurodegeneration of rat with oxidative stress induced by 3-nitropropionic acid |
| title_full | Effect of cerebrolysin on dopaminergic neurodegeneration of rat with oxidative stress induced by 3-nitropropionic acid |
| title_fullStr | Effect of cerebrolysin on dopaminergic neurodegeneration of rat with oxidative stress induced by 3-nitropropionic acid |
| title_full_unstemmed | Effect of cerebrolysin on dopaminergic neurodegeneration of rat with oxidative stress induced by 3-nitropropionic acid |
| title_short | Effect of cerebrolysin on dopaminergic neurodegeneration of rat with oxidative stress induced by 3-nitropropionic acid |
| title_sort | effect of cerebrolysin on dopaminergic neurodegeneration of rat with oxidative stress induced by 3 nitropropionic acid |
| topic | cerebrolysin dopamine 3-nitropropionic acid oxidative stress |
| url | https://doi.org/10.1515/acph-2016-0027 |
| work_keys_str_mv | AT calderonguzmandavid effectofcerebrolysinondopaminergicneurodegenerationofratwithoxidativestressinducedby3nitropropionicacid AT brizuelanormaosnaya effectofcerebrolysinondopaminergicneurodegenerationofratwithoxidativestressinducedby3nitropropionicacid AT ortizherreramaribel effectofcerebrolysinondopaminergicneurodegenerationofratwithoxidativestressinducedby3nitropropionicacid AT hernandezgarciaernestina effectofcerebrolysinondopaminergicneurodegenerationofratwithoxidativestressinducedby3nitropropionicacid AT barraganmejiagerardo effectofcerebrolysinondopaminergicneurodegenerationofratwithoxidativestressinducedby3nitropropionicacid AT juarezolguinhugo effectofcerebrolysinondopaminergicneurodegenerationofratwithoxidativestressinducedby3nitropropionicacid AT valenzuelaperazaarmando effectofcerebrolysinondopaminergicneurodegenerationofratwithoxidativestressinducedby3nitropropionicacid AT attilusjonas effectofcerebrolysinondopaminergicneurodegenerationofratwithoxidativestressinducedby3nitropropionicacid AT labraruiznorma effectofcerebrolysinondopaminergicneurodegenerationofratwithoxidativestressinducedby3nitropropionicacid |