The Function of Necroptosis and Its Treatment Target in IBD
Inflammatory bowel disease (IBD), which encompasses Crohn’s disease (CD) and ulcerative colitis (UC), is a complicated illness whose exact cause is yet unknown. Necroptosis is associated with IBD pathogenesis, leading to intestinal barrier abnormalities and uncontrolled inflammation. Molecules invol...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2024-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2024/7275309 |
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| author | Francis Atim Akanyibah Yi Zhu Tao Jin Dickson Kofi Wiredu Ocansey Fei Mao Wei Qiu |
| author_facet | Francis Atim Akanyibah Yi Zhu Tao Jin Dickson Kofi Wiredu Ocansey Fei Mao Wei Qiu |
| author_sort | Francis Atim Akanyibah |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD), which encompasses Crohn’s disease (CD) and ulcerative colitis (UC), is a complicated illness whose exact cause is yet unknown. Necroptosis is associated with IBD pathogenesis, leading to intestinal barrier abnormalities and uncontrolled inflammation. Molecules involved in necroptosis, however, exhibit different expression levels in IBD and its associated colorectal cancer. Multiple studies have shown that inhibiting these molecules alleviates necroptosis-induced IBD. Moreover, due to the severe scarcity of clinical medications for treating IBD caused by necroptosis, we review the various functions of crucial necroptosis molecules in IBD, the stimuli regulating necroptosis, and the current emerging therapeutic strategies for treating IBD-associated necroptosis. Eventually, understanding the pathogenesis of necroptosis in IBD will enable the development of additional therapeutic approaches for the illness. |
| format | Article |
| id | doaj-art-63a64df912bd4421b042e3475690769e |
| institution | Kabale University |
| issn | 1466-1861 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-63a64df912bd4421b042e3475690769e2025-02-03T05:54:37ZengWileyMediators of Inflammation1466-18612024-01-01202410.1155/2024/7275309The Function of Necroptosis and Its Treatment Target in IBDFrancis Atim Akanyibah0Yi Zhu1Tao Jin2Dickson Kofi Wiredu Ocansey3Fei Mao4Wei Qiu5Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu ProvinceThe People’s Hospital of DanyangDepartment of Gastrointestinal and EndoscopyKey Laboratory of Medical Science and Laboratory Medicine of Jiangsu ProvinceKey Laboratory of Medical Science and Laboratory Medicine of Jiangsu ProvinceNanjing Jiangning HospitalInflammatory bowel disease (IBD), which encompasses Crohn’s disease (CD) and ulcerative colitis (UC), is a complicated illness whose exact cause is yet unknown. Necroptosis is associated with IBD pathogenesis, leading to intestinal barrier abnormalities and uncontrolled inflammation. Molecules involved in necroptosis, however, exhibit different expression levels in IBD and its associated colorectal cancer. Multiple studies have shown that inhibiting these molecules alleviates necroptosis-induced IBD. Moreover, due to the severe scarcity of clinical medications for treating IBD caused by necroptosis, we review the various functions of crucial necroptosis molecules in IBD, the stimuli regulating necroptosis, and the current emerging therapeutic strategies for treating IBD-associated necroptosis. Eventually, understanding the pathogenesis of necroptosis in IBD will enable the development of additional therapeutic approaches for the illness.http://dx.doi.org/10.1155/2024/7275309 |
| spellingShingle | Francis Atim Akanyibah Yi Zhu Tao Jin Dickson Kofi Wiredu Ocansey Fei Mao Wei Qiu The Function of Necroptosis and Its Treatment Target in IBD Mediators of Inflammation |
| title | The Function of Necroptosis and Its Treatment Target in IBD |
| title_full | The Function of Necroptosis and Its Treatment Target in IBD |
| title_fullStr | The Function of Necroptosis and Its Treatment Target in IBD |
| title_full_unstemmed | The Function of Necroptosis and Its Treatment Target in IBD |
| title_short | The Function of Necroptosis and Its Treatment Target in IBD |
| title_sort | function of necroptosis and its treatment target in ibd |
| url | http://dx.doi.org/10.1155/2024/7275309 |
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