A New In Vivo Model System to Assess the Toxicity of Semiconductor Nanocrystals
In the emerging area of nanotechnology, a key issue is related to the potential impacts of the novel nanomaterials on the environment and human health, so that this technology can be used with minimal risk. Specifically designed to combine on a single structure multipurpose tags and properties, smar...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2011-01-01
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| Series: | International Journal of Biomaterials |
| Online Access: | http://dx.doi.org/10.1155/2011/792854 |
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| _version_ | 1832550790264258560 |
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| author | Angela Tino Alfredo Ambrosone Lucia Mattera Valentina Marchesano Andrei Susha Andrey Rogach Claudia Tortiglione |
| author_facet | Angela Tino Alfredo Ambrosone Lucia Mattera Valentina Marchesano Andrei Susha Andrey Rogach Claudia Tortiglione |
| author_sort | Angela Tino |
| collection | DOAJ |
| description | In the emerging area of nanotechnology, a key issue is related to the potential impacts of the novel nanomaterials on the environment and human health, so that this technology can be used with minimal risk. Specifically designed to combine on a single structure multipurpose tags and properties, smart nanomaterials need a comprehensive characterization of both chemicophysical properties and adequate toxicological evaluation, which is a challenging endeavour; the in vitro toxicity assays that are often employed for nanotoxicity assessments do not accurately predict in vivo response. To overcome these limitations and to evaluate toxicity characteristics of cadmium telluride quantum dots in relation to surface coatings, we have employed the freshwater polyp Hydra vulgaris as a model system. We assessed in vivo acute and sublethal toxicity by scoring for alteration of morphological traits, population growth rates, and influence on the regenerative capabilities providing new investigation clues for nanotoxicology purposes. |
| format | Article |
| id | doaj-art-6362456c9b2c4469a906d7ca22255abd |
| institution | Kabale University |
| issn | 1687-8787 1687-8795 |
| language | English |
| publishDate | 2011-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Biomaterials |
| spelling | doaj-art-6362456c9b2c4469a906d7ca22255abd2025-02-03T06:05:50ZengWileyInternational Journal of Biomaterials1687-87871687-87952011-01-01201110.1155/2011/792854792854A New In Vivo Model System to Assess the Toxicity of Semiconductor NanocrystalsAngela Tino0Alfredo Ambrosone1Lucia Mattera2Valentina Marchesano3Andrei Susha4Andrey Rogach5Claudia Tortiglione6Institute of Cybernetics “E. Caianiello”, National Research Council of Italy, Via Campi Flegrei, 34, 80078 Pozzuoli, ItalyInstitute of Cybernetics “E. Caianiello”, National Research Council of Italy, Via Campi Flegrei, 34, 80078 Pozzuoli, ItalyInstitute of Cybernetics “E. Caianiello”, National Research Council of Italy, Via Campi Flegrei, 34, 80078 Pozzuoli, ItalyInstitute of Cybernetics “E. Caianiello”, National Research Council of Italy, Via Campi Flegrei, 34, 80078 Pozzuoli, ItalyDepartment of Physics and Materials Science, City University of Hong Kong, Hong Kong SAR, Kowloon, ChinaDepartment of Physics and Materials Science, City University of Hong Kong, Hong Kong SAR, Kowloon, ChinaInstitute of Cybernetics “E. Caianiello”, National Research Council of Italy, Via Campi Flegrei, 34, 80078 Pozzuoli, ItalyIn the emerging area of nanotechnology, a key issue is related to the potential impacts of the novel nanomaterials on the environment and human health, so that this technology can be used with minimal risk. Specifically designed to combine on a single structure multipurpose tags and properties, smart nanomaterials need a comprehensive characterization of both chemicophysical properties and adequate toxicological evaluation, which is a challenging endeavour; the in vitro toxicity assays that are often employed for nanotoxicity assessments do not accurately predict in vivo response. To overcome these limitations and to evaluate toxicity characteristics of cadmium telluride quantum dots in relation to surface coatings, we have employed the freshwater polyp Hydra vulgaris as a model system. We assessed in vivo acute and sublethal toxicity by scoring for alteration of morphological traits, population growth rates, and influence on the regenerative capabilities providing new investigation clues for nanotoxicology purposes.http://dx.doi.org/10.1155/2011/792854 |
| spellingShingle | Angela Tino Alfredo Ambrosone Lucia Mattera Valentina Marchesano Andrei Susha Andrey Rogach Claudia Tortiglione A New In Vivo Model System to Assess the Toxicity of Semiconductor Nanocrystals International Journal of Biomaterials |
| title | A New In Vivo Model System to Assess the Toxicity of Semiconductor Nanocrystals |
| title_full | A New In Vivo Model System to Assess the Toxicity of Semiconductor Nanocrystals |
| title_fullStr | A New In Vivo Model System to Assess the Toxicity of Semiconductor Nanocrystals |
| title_full_unstemmed | A New In Vivo Model System to Assess the Toxicity of Semiconductor Nanocrystals |
| title_short | A New In Vivo Model System to Assess the Toxicity of Semiconductor Nanocrystals |
| title_sort | new in vivo model system to assess the toxicity of semiconductor nanocrystals |
| url | http://dx.doi.org/10.1155/2011/792854 |
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