Enteric Fever as an Antecedent to Development of Miller-Fisher Syndrome and Possible Role of COVID-19 Vaccination
Summary: Guillain-Barre Syndrome is an immune-mediated demyelinating disorder. Miller-Fisher Syndrome is an uncommon subtype of GBS. It is characterized by findings of ophthalmoplegia, ataxia, and areflexia. Here we present the case of Miller-Fisher Syndrome following an episode of typhoidal diarrh...
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| Format: | Article |
| Language: | English |
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Rawalpindi Medical University
2023-12-01
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| Series: | Journal of Rawalpindi Medical College |
| Online Access: | https://www.journalrmc.com/index.php/JRMC/article/view/2289 |
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| author | Tayyaba Binte Saleem Muhammad Ibrahim Faizan Fazal Mohammad Ebad Ur Rehman Ali Ahmad Ijaz Humera Nasim |
| author_facet | Tayyaba Binte Saleem Muhammad Ibrahim Faizan Fazal Mohammad Ebad Ur Rehman Ali Ahmad Ijaz Humera Nasim |
| author_sort | Tayyaba Binte Saleem |
| collection | DOAJ |
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Summary: Guillain-Barre Syndrome is an immune-mediated demyelinating disorder. Miller-Fisher Syndrome is an uncommon subtype of GBS. It is characterized by findings of ophthalmoplegia, ataxia, and areflexia. Here we present the case of Miller-Fisher Syndrome following an episode of typhoidal diarrhea. The presentation was of rapidly progressing weakness beginning in the lower extremity with diplopia. Examination revealed diminished reflexes. CSF testing revealed albuminocytologic dissociation which was later supported by neurophysiological testing. The patient was treated with intravenous immunoglobulins (IVIG).
We conclude that Miller-Fisher syndrome should be considered in the diagnostic workup of patients presenting with new sensorimotor deficits following diarrheal illnesses and/or COVID-19 mRNA vaccination. Early recognition is essential given the propensity of GBS to cause life-threatening respiratory failure and prompt IVIG administration is associated with a better prognosis.
Keywords: Enteric Fever, Miller-Fisher Syndrome, COVID-19, Vaccination
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| format | Article |
| id | doaj-art-6355691f53364563b1bb673a7b501b4c |
| institution | Kabale University |
| issn | 1683-3562 1683-3570 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Rawalpindi Medical University |
| record_format | Article |
| series | Journal of Rawalpindi Medical College |
| spelling | doaj-art-6355691f53364563b1bb673a7b501b4c2025-02-06T08:40:37ZengRawalpindi Medical UniversityJournal of Rawalpindi Medical College1683-35621683-35702023-12-0127410.37939/jrmc.v27i4.2289Enteric Fever as an Antecedent to Development of Miller-Fisher Syndrome and Possible Role of COVID-19 VaccinationTayyaba Binte SaleemMuhammad IbrahimFaizan Fazal0Mohammad Ebad Ur RehmanAli Ahmad IjazHumera NasimRawalpindi Medical University Summary: Guillain-Barre Syndrome is an immune-mediated demyelinating disorder. Miller-Fisher Syndrome is an uncommon subtype of GBS. It is characterized by findings of ophthalmoplegia, ataxia, and areflexia. Here we present the case of Miller-Fisher Syndrome following an episode of typhoidal diarrhea. The presentation was of rapidly progressing weakness beginning in the lower extremity with diplopia. Examination revealed diminished reflexes. CSF testing revealed albuminocytologic dissociation which was later supported by neurophysiological testing. The patient was treated with intravenous immunoglobulins (IVIG). We conclude that Miller-Fisher syndrome should be considered in the diagnostic workup of patients presenting with new sensorimotor deficits following diarrheal illnesses and/or COVID-19 mRNA vaccination. Early recognition is essential given the propensity of GBS to cause life-threatening respiratory failure and prompt IVIG administration is associated with a better prognosis. Keywords: Enteric Fever, Miller-Fisher Syndrome, COVID-19, Vaccination https://www.journalrmc.com/index.php/JRMC/article/view/2289 |
| spellingShingle | Tayyaba Binte Saleem Muhammad Ibrahim Faizan Fazal Mohammad Ebad Ur Rehman Ali Ahmad Ijaz Humera Nasim Enteric Fever as an Antecedent to Development of Miller-Fisher Syndrome and Possible Role of COVID-19 Vaccination Journal of Rawalpindi Medical College |
| title | Enteric Fever as an Antecedent to Development of Miller-Fisher Syndrome and Possible Role of COVID-19 Vaccination |
| title_full | Enteric Fever as an Antecedent to Development of Miller-Fisher Syndrome and Possible Role of COVID-19 Vaccination |
| title_fullStr | Enteric Fever as an Antecedent to Development of Miller-Fisher Syndrome and Possible Role of COVID-19 Vaccination |
| title_full_unstemmed | Enteric Fever as an Antecedent to Development of Miller-Fisher Syndrome and Possible Role of COVID-19 Vaccination |
| title_short | Enteric Fever as an Antecedent to Development of Miller-Fisher Syndrome and Possible Role of COVID-19 Vaccination |
| title_sort | enteric fever as an antecedent to development of miller fisher syndrome and possible role of covid 19 vaccination |
| url | https://www.journalrmc.com/index.php/JRMC/article/view/2289 |
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