Production and development of vaccines for ornithobacterium rhinotracheale infection in turkeys
<b>Aim:</b> The purpose of this study was to prepare bivalent inactive Ornithobacterium rhinotracheale bacterin vaccines to measure the levels of antibodies against antigens in blood sera and to determine the efficacies of different O. rhinotracheale vaccines on turkeys.<p> <b&g...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Selcuk University Press
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| Series: | Eurasian Journal of Veterinary Sciences |
| Subjects: | |
| Online Access: | http://eurasianjvetsci.org/pdf.php3?id=567 |
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| Summary: | <b>Aim:</b> The purpose of this study was to prepare bivalent inactive
Ornithobacterium rhinotracheale bacterin vaccines to
measure the levels of antibodies against antigens in blood
sera and to determine the efficacies of different O. rhinotracheale
vaccines on turkeys.<p>
<b>Materials and Methods:</b> The bivalent inactivated O. rhinotracheale
bacterin vaccines were prepared from O. rhinotracheale
serotype A and B strains using aliminium hydroxide,
mineral oil, aluminium hydroxide + ginseng and mineral oil
+ ginseng. After the sterility and the safety tests, laboratory
efficiencies of vaccines (challange/protection and serological
potency) were done on the turkeys (twice vaccinated
with doses 0.25 ml and 0.5 ml at 5 and 8 weeks, respectively).<p>
<b>Results:</b> According to the challenge results, all the vaccines
were found effective at 100%. Slide agglutination, micro
serum agglutination and ELISA tests were used for the diagnosis.
The vaccine containing mineral oil and ginseng as
adjuvant induced significantly greater humoral immune response
than others. Also, vaccine containing mineral oil and
ginseng as adjuvant was determined to be more effective in
the field trials in a company privately producing turkeys.<p>
<b>Conclusion:</b> O. rhinotracheale vaccines could be used for
prevention of ornithobacteriosis in turkeys. |
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| ISSN: | 1309-6958 2146-1953 |