The Impact of Migraine on the Whole Life Course of Patients: Results from the OVERCOME (Japan) 2nd Study
Abstract Introduction The impact of migraine on patients’ lives, including challenges they face before getting access to appropriate medical management, is not well understood. The ObserVational survey of the Epidemiology, tReatment, and Care Of MigrainE [OVERCOME (Japan)] 2nd study was conducted to...
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| Format: | Article |
| Language: | English |
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Adis, Springer Healthcare
2024-12-01
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| Series: | Neurology and Therapy |
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| Online Access: | https://doi.org/10.1007/s40120-024-00690-x |
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| author | Daisuke Danno Shiho Suzuki Tsubasa Takizawa Ryotaro Ishii Masayuki Hamakawa Yoshinori Tanizawa Satoshi Osaga Mika Komori |
| author_facet | Daisuke Danno Shiho Suzuki Tsubasa Takizawa Ryotaro Ishii Masayuki Hamakawa Yoshinori Tanizawa Satoshi Osaga Mika Komori |
| author_sort | Daisuke Danno |
| collection | DOAJ |
| description | Abstract Introduction The impact of migraine on patients’ lives, including challenges they face before getting access to appropriate medical management, is not well understood. The ObserVational survey of the Epidemiology, tReatment, and Care Of MigrainE [OVERCOME (Japan)] 2nd study was conducted to provide information regarding burden and experience with migraine throughout the life course. Methods This cross-sectional, population-based, nationwide online survey was conducted in adults with or without migraine. The migraine group reported their headache features and experiences in medical management since headache onset. Migraine’s burden and impact were assessed with various PRO instruments. Migraine and non-migraine groups reported their experiences in life events and answered questions on self-esteem. Subgroup analyses by the number of monthly headache days (MHD) were performed. Results The migraine group (n = 19,590) was numerically younger [mean (SD) age 40.5 (13.1) years vs. 53.1 (17.8) years] and included more females (68.8% vs. 52.1%) than the non-migraine group (n = 2219). The migraine group had mean (SD) 3.5 (5.2) MHDs; 24.2–56.7% had moderate-to-very severe disease burden per various PRO instruments. Headaches started when respondents with migraine were 17.8 years old; 86.7% started over-the-counter medications at 19.4 years of age. Only 46.4% self-reported migraine diagnosis by a physician and 25.1% received an oral preventive drug, almost a decade after headache onset. Up to 16.8% reported poor support/lack of understanding from either teachers or parents during school life. The migraine group had numerically more frequent job changes and divorce, and lower self-esteem, than the non-migraine group. Across assessments, increased MHDs tended to worsen outcomes. Conclusion Migraine affected many individuals from an early stage, but timely support and medical intervention were insufficient. This may negatively impact important life events, cause long-term impairment, and decrease self-esteem. Hence, improving the social understanding and medical environment for migraine to provide timely support is essential. |
| format | Article |
| id | doaj-art-631e48cc6c17447bb5c2841ce3e97dfd |
| institution | Kabale University |
| issn | 2193-8253 2193-6536 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Adis, Springer Healthcare |
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| series | Neurology and Therapy |
| spelling | doaj-art-631e48cc6c17447bb5c2841ce3e97dfd2025-01-26T12:58:47ZengAdis, Springer HealthcareNeurology and Therapy2193-82532193-65362024-12-0114133535610.1007/s40120-024-00690-xThe Impact of Migraine on the Whole Life Course of Patients: Results from the OVERCOME (Japan) 2nd StudyDaisuke Danno0Shiho Suzuki1Tsubasa Takizawa2Ryotaro Ishii3Masayuki Hamakawa4Yoshinori Tanizawa5Satoshi Osaga6Mika Komori7Tominaga HospitalDokkyo Medical UniversityKeio University School of MedicineKyoto Prefectural University of MedicineSocial Survey Research Information Co., LtdEli Lilly Japan K.K.Eli Lilly Japan K.K.Eli Lilly Japan K.K.Abstract Introduction The impact of migraine on patients’ lives, including challenges they face before getting access to appropriate medical management, is not well understood. The ObserVational survey of the Epidemiology, tReatment, and Care Of MigrainE [OVERCOME (Japan)] 2nd study was conducted to provide information regarding burden and experience with migraine throughout the life course. Methods This cross-sectional, population-based, nationwide online survey was conducted in adults with or without migraine. The migraine group reported their headache features and experiences in medical management since headache onset. Migraine’s burden and impact were assessed with various PRO instruments. Migraine and non-migraine groups reported their experiences in life events and answered questions on self-esteem. Subgroup analyses by the number of monthly headache days (MHD) were performed. Results The migraine group (n = 19,590) was numerically younger [mean (SD) age 40.5 (13.1) years vs. 53.1 (17.8) years] and included more females (68.8% vs. 52.1%) than the non-migraine group (n = 2219). The migraine group had mean (SD) 3.5 (5.2) MHDs; 24.2–56.7% had moderate-to-very severe disease burden per various PRO instruments. Headaches started when respondents with migraine were 17.8 years old; 86.7% started over-the-counter medications at 19.4 years of age. Only 46.4% self-reported migraine diagnosis by a physician and 25.1% received an oral preventive drug, almost a decade after headache onset. Up to 16.8% reported poor support/lack of understanding from either teachers or parents during school life. The migraine group had numerically more frequent job changes and divorce, and lower self-esteem, than the non-migraine group. Across assessments, increased MHDs tended to worsen outcomes. Conclusion Migraine affected many individuals from an early stage, but timely support and medical intervention were insufficient. This may negatively impact important life events, cause long-term impairment, and decrease self-esteem. Hence, improving the social understanding and medical environment for migraine to provide timely support is essential.https://doi.org/10.1007/s40120-024-00690-xBurdenPatient-reported outcomeSurveyHeadacheAcute medicationPreventive medication |
| spellingShingle | Daisuke Danno Shiho Suzuki Tsubasa Takizawa Ryotaro Ishii Masayuki Hamakawa Yoshinori Tanizawa Satoshi Osaga Mika Komori The Impact of Migraine on the Whole Life Course of Patients: Results from the OVERCOME (Japan) 2nd Study Neurology and Therapy Burden Patient-reported outcome Survey Headache Acute medication Preventive medication |
| title | The Impact of Migraine on the Whole Life Course of Patients: Results from the OVERCOME (Japan) 2nd Study |
| title_full | The Impact of Migraine on the Whole Life Course of Patients: Results from the OVERCOME (Japan) 2nd Study |
| title_fullStr | The Impact of Migraine on the Whole Life Course of Patients: Results from the OVERCOME (Japan) 2nd Study |
| title_full_unstemmed | The Impact of Migraine on the Whole Life Course of Patients: Results from the OVERCOME (Japan) 2nd Study |
| title_short | The Impact of Migraine on the Whole Life Course of Patients: Results from the OVERCOME (Japan) 2nd Study |
| title_sort | impact of migraine on the whole life course of patients results from the overcome japan 2nd study |
| topic | Burden Patient-reported outcome Survey Headache Acute medication Preventive medication |
| url | https://doi.org/10.1007/s40120-024-00690-x |
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