Human Fcγ-receptors selectively respond to C-reactive protein isoforms

Human Fcγ-receptors selectively respond to C-reactive protein isoforms

IntroductionThe pentameric C-reactive protein (pCRP), an acute-phase protein, binds to lysophosphatidylcholine (LPC) displayed on the surface of dying cells and microorganisms to activate the complement system and to opsonize immune cells via Fcγ-receptors (FcγRs). Members of the FcγR family are cha...

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Bibliographic Details
Main Authors: Anna Henning, Johanna Seer, Johannes Zeller, Karlheinz Peter, Haizhang Chen, Julia Thomé, Philipp Kolb, Steffen U. Eisenhardt, Katja Hoffmann, Hartmut Hengel
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
C-reactive protein
CRP isoforms
Fcγ receptor
immunoglobulin
immune complex
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1598605/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1598605/full

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