The utility of preemptive mass influenza vaccination in controlling a SARS outbreak during flu season
During flu season, respiratory infections can cause non-specificinfluenza-like-illnesses (ILIs) in up to one-half of the general population. If afuture SARS outbreak were to coincide with flu season, it would become exceptionallydifficult to distinguish SARS rapidly and accurately from other ILIs,...
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| Format: | Article |
| Language: | English |
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AIMS Press
2007-07-01
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| Series: | Mathematical Biosciences and Engineering |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2007.4.739 |
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| author | Qingling Zeng Kamran Khan Jianhong Wu Huaiping Zhu |
| author_facet | Qingling Zeng Kamran Khan Jianhong Wu Huaiping Zhu |
| author_sort | Qingling Zeng |
| collection | DOAJ |
| description | During flu season, respiratory infections can cause non-specificinfluenza-like-illnesses (ILIs) in up to one-half of the general population. If afuture SARS outbreak were to coincide with flu season, it would become exceptionallydifficult to distinguish SARS rapidly and accurately from other ILIs, given thenon-specific clinical presentation of SARS and the current lack of a widely available,rapid, diagnostic test. We construct a deterministic compartmental model to examine thepotential impact of preemptive mass influenza vaccination on SARS containment during ahypothetical SARS outbreak coinciding with a peak flu season. Our model was developedbased upon the events of the 2003 SARS outbreak in Toronto, Canada. The relationship ofdifferent vaccination rates for influenza and the corresponding required quarantinerates for individuals who are exposed to SARS was analyzed and simulated under differentassumptions. The study revealed that a campaign of mass influenza vaccination prior tothe onset of flu season could aid the containment of a future SARS outbreak bydecreasing the total number of persons with ILIs presenting to the health-care system,and consequently decreasing nosocomial transmission of SARS in persons underinvestigation for the disease. |
| format | Article |
| id | doaj-art-62f1d3478af44e7bb2d2ec21acda1377 |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2007-07-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-62f1d3478af44e7bb2d2ec21acda13772025-01-24T01:54:07ZengAIMS PressMathematical Biosciences and Engineering1551-00182007-07-014473975410.3934/mbe.2007.4.739The utility of preemptive mass influenza vaccination in controlling a SARS outbreak during flu seasonQingling Zeng0Kamran Khan1Jianhong Wu2Huaiping Zhu3Department of Mathematics and Statistics, York University, 4700 Keele Street, Toronto, ON M3J 1P3Department of Mathematics and Statistics, York University, 4700 Keele Street, Toronto, ON M3J 1P3Department of Mathematics and Statistics, York University, 4700 Keele Street, Toronto, ON M3J 1P3Department of Mathematics and Statistics, York University, 4700 Keele Street, Toronto, ON M3J 1P3During flu season, respiratory infections can cause non-specificinfluenza-like-illnesses (ILIs) in up to one-half of the general population. If afuture SARS outbreak were to coincide with flu season, it would become exceptionallydifficult to distinguish SARS rapidly and accurately from other ILIs, given thenon-specific clinical presentation of SARS and the current lack of a widely available,rapid, diagnostic test. We construct a deterministic compartmental model to examine thepotential impact of preemptive mass influenza vaccination on SARS containment during ahypothetical SARS outbreak coinciding with a peak flu season. Our model was developedbased upon the events of the 2003 SARS outbreak in Toronto, Canada. The relationship ofdifferent vaccination rates for influenza and the corresponding required quarantinerates for individuals who are exposed to SARS was analyzed and simulated under differentassumptions. The study revealed that a campaign of mass influenza vaccination prior tothe onset of flu season could aid the containment of a future SARS outbreak bydecreasing the total number of persons with ILIs presenting to the health-care system,and consequently decreasing nosocomial transmission of SARS in persons underinvestigation for the disease.https://www.aimspress.com/article/doi/10.3934/mbe.2007.4.739disease outbreakstheoretical models.mass immunizationrespiratory tractinfectionsinfluenzasevere acute respiratory syndrome (sars) |
| spellingShingle | Qingling Zeng Kamran Khan Jianhong Wu Huaiping Zhu The utility of preemptive mass influenza vaccination in controlling a SARS outbreak during flu season Mathematical Biosciences and Engineering disease outbreaks theoretical models. mass immunization respiratory tractinfections influenza severe acute respiratory syndrome (sars) |
| title | The utility of preemptive mass influenza vaccination in controlling a SARS outbreak during flu season |
| title_full | The utility of preemptive mass influenza vaccination in controlling a SARS outbreak during flu season |
| title_fullStr | The utility of preemptive mass influenza vaccination in controlling a SARS outbreak during flu season |
| title_full_unstemmed | The utility of preemptive mass influenza vaccination in controlling a SARS outbreak during flu season |
| title_short | The utility of preemptive mass influenza vaccination in controlling a SARS outbreak during flu season |
| title_sort | utility of preemptive mass influenza vaccination in controlling a sars outbreak during flu season |
| topic | disease outbreaks theoretical models. mass immunization respiratory tractinfections influenza severe acute respiratory syndrome (sars) |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2007.4.739 |
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