Cell type-specific multi-omics analysis of cocaine use disorder in the human caudate nucleus

Cell type-specific multi-omics analysis of cocaine use disorder in the human caudate nucleus

Abstract Structural and functional alterations in the brain’s reward circuitry are present in cocaine use disorder (CocUD), but their molecular underpinnings remain unclear. To investigate these mechanisms, we performed single-nuclei multiome profiling on postmortem caudate nucleus tissue from six i...

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Main Authors: Lea Zillich, Annasara Artioli, Veronika Pohořalá, Eric Zillich, Laura Stertz, Hanna Belschner, Ammar Jabali, Josef Frank, Fabian Streit, Diana Avetyan, Maja P. Völker, Svenja Müller, Anita C. Hansson, Thomas D. Meyer, Marcella Rietschel, Julia Ladewig, Rainer Spanagel, Ana M. M. Oliveira, Consuelo Walss-Bass, Rick E. Bernardi, Philipp Koch, Stephanie H. Witt
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57339-y
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https://doi.org/10.1038/s41467-025-57339-y

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