Effects of Maackia amurensis seed lectin (MASL) on OSCC cell morphology, PDPN expression, growth, and motility in a phase 1 clinical trial

Effects of Maackia amurensis seed lectin (MASL) on OSCC cell morphology, PDPN expression, growth, and motility in a phase 1 clinical trial

Abstract Background Podoplanin (PDPN) has emerged as a functionally relevant biomarker and chemotherapeutic target expressed by OSCC cells. PDPN signaling can directly increase tumor cell invasion and metastasis, and also inhibit host lymphocyte activation and immune response. Accordingly, antibodie...

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Main Authors: Ariel C. Yin, Cayla J. Holdcraft, Tyler J. Helmig, Eamonn J. Brace, David I. Suster, Alan J. Shienbaum, Dylan Roden, Evelyne Kalyoussef, Ghayoour Mir, Eugenio Capitle, Soly Baredes, Rabie M. Shanti, Mika K. Kaneko, Yukinari Kato, Hisataka Kobayashi, Aki Furusawa, Mahnaz Fatahzadeh, Gary S. Goldberg
Format: Article
Language:English
Published: Springer 2025-07-01
Series:Journal of Cancer Research and Clinical Oncology
Subjects:
Keywords: Maackia amurensis seed lectin
MASL
Oral cancer
Oral squamous cell carcinoma
OSCC
PDPN
Online Access:https://doi.org/10.1007/s00432-025-06265-z
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https://doi.org/10.1007/s00432-025-06265-z

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