Amelioration of metabolic disorders by a mushroom-derived polyphenols correlates with the reduction of Ruminococcaceae in gut of DIO mice
A polyphenolic alkaloid-enriched extract (PAE) was prepared from the fruiting bodies of a wild edible mushroom Sarcodon leucopus. Oral administration of PAE reduced hyperglycemia, hyperlipidemia, hepatic steatosis, and LPS-related inflammation in high fat diet-induced obese (DIO) mice. Furthermore,...
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Tsinghua University Press
2021-07-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213453021000537 |
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| author | Li Sun Li Bao Dorji Phurbu Shanshan Qiao Shanshan Sun Yangzom Perma Hongwei Liu |
| author_facet | Li Sun Li Bao Dorji Phurbu Shanshan Qiao Shanshan Sun Yangzom Perma Hongwei Liu |
| author_sort | Li Sun |
| collection | DOAJ |
| description | A polyphenolic alkaloid-enriched extract (PAE) was prepared from the fruiting bodies of a wild edible mushroom Sarcodon leucopus. Oral administration of PAE reduced hyperglycemia, hyperlipidemia, hepatic steatosis, and LPS-related inflammation in high fat diet-induced obese (DIO) mice. Furthermore, we show that PAE produces taxonomic and predicted functional changes in the gut microbiome of DIO mice. A significant decrease in the family of Ruminococcaceae, especially the secondary bile acid-producing bacteria of Intestinimonas and Anaerotruncus, is detected in the gut microbiome of PAE-treate mice. Accordingly, reductions of deoxycholic acid and lithocholic acid are found in the feces of PAE-treated DIO mice, which benefits for the intestinal integrity and the reduction of inflammation. A gut microbiota related mechanism for the anti-metabolic syndrome effects of the PAE is proposed. We suppose the polyphenolic alkaloid extract from S. leucopus be a new and beneficial prebiotic regulating glucose and lipid metabolisms. |
| format | Article |
| id | doaj-art-62d4b08bbf2545a1bfd97415f961fca1 |
| institution | Kabale University |
| issn | 2213-4530 |
| language | English |
| publishDate | 2021-07-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-62d4b08bbf2545a1bfd97415f961fca12025-02-03T05:18:36ZengTsinghua University PressFood Science and Human Wellness2213-45302021-07-01104442451Amelioration of metabolic disorders by a mushroom-derived polyphenols correlates with the reduction of Ruminococcaceae in gut of DIO miceLi Sun0Li Bao1Dorji Phurbu2Shanshan Qiao3Shanshan Sun4Yangzom Perma5Hongwei Liu6State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100864, China; Savaid Medicine School, University of Chinese Academy of Sciences, Beijing 100864, ChinaBeijing Shijitan Hospital, Capital Medicinal University, Beijing 100864, ChinaTibet Plateau Institute of Biology, Lhasa 850000, ChinaState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100864, China; Savaid Medicine School, University of Chinese Academy of Sciences, Beijing 100864, ChinaState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100864, China; School of Life Sciences, University of Science and Technology of China, Hefei 230026, ChinaTibet Plateau Institute of Biology, Lhasa 850000, ChinaState Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100864, China; Savaid Medicine School, University of Chinese Academy of Sciences, Beijing 100864, China; Corresponding author.A polyphenolic alkaloid-enriched extract (PAE) was prepared from the fruiting bodies of a wild edible mushroom Sarcodon leucopus. Oral administration of PAE reduced hyperglycemia, hyperlipidemia, hepatic steatosis, and LPS-related inflammation in high fat diet-induced obese (DIO) mice. Furthermore, we show that PAE produces taxonomic and predicted functional changes in the gut microbiome of DIO mice. A significant decrease in the family of Ruminococcaceae, especially the secondary bile acid-producing bacteria of Intestinimonas and Anaerotruncus, is detected in the gut microbiome of PAE-treate mice. Accordingly, reductions of deoxycholic acid and lithocholic acid are found in the feces of PAE-treated DIO mice, which benefits for the intestinal integrity and the reduction of inflammation. A gut microbiota related mechanism for the anti-metabolic syndrome effects of the PAE is proposed. We suppose the polyphenolic alkaloid extract from S. leucopus be a new and beneficial prebiotic regulating glucose and lipid metabolisms.http://www.sciencedirect.com/science/article/pii/S2213453021000537Sarcodon leucopusPolyphenolic alkaloidsMetabolic syndromeGut microbiotaRuminococcaceae |
| spellingShingle | Li Sun Li Bao Dorji Phurbu Shanshan Qiao Shanshan Sun Yangzom Perma Hongwei Liu Amelioration of metabolic disorders by a mushroom-derived polyphenols correlates with the reduction of Ruminococcaceae in gut of DIO mice Food Science and Human Wellness Sarcodon leucopus Polyphenolic alkaloids Metabolic syndrome Gut microbiota Ruminococcaceae |
| title | Amelioration of metabolic disorders by a mushroom-derived polyphenols correlates with the reduction of Ruminococcaceae in gut of DIO mice |
| title_full | Amelioration of metabolic disorders by a mushroom-derived polyphenols correlates with the reduction of Ruminococcaceae in gut of DIO mice |
| title_fullStr | Amelioration of metabolic disorders by a mushroom-derived polyphenols correlates with the reduction of Ruminococcaceae in gut of DIO mice |
| title_full_unstemmed | Amelioration of metabolic disorders by a mushroom-derived polyphenols correlates with the reduction of Ruminococcaceae in gut of DIO mice |
| title_short | Amelioration of metabolic disorders by a mushroom-derived polyphenols correlates with the reduction of Ruminococcaceae in gut of DIO mice |
| title_sort | amelioration of metabolic disorders by a mushroom derived polyphenols correlates with the reduction of ruminococcaceae in gut of dio mice |
| topic | Sarcodon leucopus Polyphenolic alkaloids Metabolic syndrome Gut microbiota Ruminococcaceae |
| url | http://www.sciencedirect.com/science/article/pii/S2213453021000537 |
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