Hp eradication decreased the expression level of PG II in patients of Hp negative with gastric intestinal metaplasia: a retrospective cross-sectional study
Abstract Aims This study aims to assess the serum levels of pepsinogen (PG)I, PG II, and gastrin (G17) in patients with gastric intestinal metaplasia (GIM) and evaluate their correlation with demographic characteristics. Methods A total of 247 normal controls (NC) and 240 patients diagnosed with GIM...
Saved in:
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2025-01-01
|
| Series: | Journal of Health, Population and Nutrition |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s41043-025-00756-y |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832585639303839744 |
|---|---|
| author | Yanhong Wang Xixiang Cao Baodong Shan Song Chen Shengnan Li Sujuan Fei Xunlei Pang |
| author_facet | Yanhong Wang Xixiang Cao Baodong Shan Song Chen Shengnan Li Sujuan Fei Xunlei Pang |
| author_sort | Yanhong Wang |
| collection | DOAJ |
| description | Abstract Aims This study aims to assess the serum levels of pepsinogen (PG)I, PG II, and gastrin (G17) in patients with gastric intestinal metaplasia (GIM) and evaluate their correlation with demographic characteristics. Methods A total of 247 normal controls (NC) and 240 patients diagnosed with GIM were enrolled in this study. All participants underwent a gastroscopy procedure followed by pathological examination for diagnosis confirmation. The expression level of PGI, PG II, and G 17 was detected by fluorescence immunochromatography and Hp infection was detected by 13-carbon breath test. The demographic characteristics of the subjects were obtained through questionnaires. Results Compared to the NC group, the GIM group showed a reduction in PG II expression level [10.71(6.40,16.89) VS 9.21(6.14,14.55), p = 0.010]. GIM patients had a higher prevalence of previous Hp eradication history (14.98% VS 23.75%, p = 0.014). The low PG II group exhibited a higher incidence rate of GIM compared to the high PG II group (54.10% VS 44.44%, p = 0 0.020). In the Hp-negative(Hp-) group, there was a decrease in both PGI and PG II expression levels when compared to the Hp-positive(Hp+) group [146.73 ± 78.53 VS 125.61 ± 68.75 and 10.19(7.27, 16.58) VS 7.36(5.62,12.53), p = 0.036 and p < 0.001]. Among patients without Hp eradication history, those with low PG II levels had a higher proportion of individuals with a history of Hp eradication than those with high PG II levels (29.31% VS 3.13%, p = 0.003). Additionally, within the subgroup that underwent Hp eradication, there was a decrease in PG II expression level compared to the subgroup without Hp eradication (6.16(5.13, 7.52) VS 8.73(5.67, 13.35), p = 0.041). Conclusion The prevalence of GIM was significantly associated with low levels of PG II. There was a significant association between HP eradication history and the prevalence of GIM. Hp eradication history resulted in reduced expression levels of PG II in Hp- GIM patients. |
| format | Article |
| id | doaj-art-62c52216089847958505414457b0cd24 |
| institution | Kabale University |
| issn | 2072-1315 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Health, Population and Nutrition |
| spelling | doaj-art-62c52216089847958505414457b0cd242025-01-26T12:39:19ZengBMCJournal of Health, Population and Nutrition2072-13152025-01-014411910.1186/s41043-025-00756-yHp eradication decreased the expression level of PG II in patients of Hp negative with gastric intestinal metaplasia: a retrospective cross-sectional studyYanhong Wang0Xixiang Cao1Baodong Shan2Song Chen3Shengnan Li4Sujuan Fei5Xunlei Pang6Department of Gastroenterology, The Affiliated Hospital of Xuzhou Medical UniversityGraduate school, Xuzhou Medical UniversityGraduate school, Xuzhou Medical UniversityGraduate school, Xuzhou Medical UniversityGraduate school, Xuzhou Medical UniversityDepartment of Gastroenterology, The Affiliated Hospital of Xuzhou Medical UniversityDepartment of Gastroenterology, The Affiliated Hospital of Xuzhou Medical UniversityAbstract Aims This study aims to assess the serum levels of pepsinogen (PG)I, PG II, and gastrin (G17) in patients with gastric intestinal metaplasia (GIM) and evaluate their correlation with demographic characteristics. Methods A total of 247 normal controls (NC) and 240 patients diagnosed with GIM were enrolled in this study. All participants underwent a gastroscopy procedure followed by pathological examination for diagnosis confirmation. The expression level of PGI, PG II, and G 17 was detected by fluorescence immunochromatography and Hp infection was detected by 13-carbon breath test. The demographic characteristics of the subjects were obtained through questionnaires. Results Compared to the NC group, the GIM group showed a reduction in PG II expression level [10.71(6.40,16.89) VS 9.21(6.14,14.55), p = 0.010]. GIM patients had a higher prevalence of previous Hp eradication history (14.98% VS 23.75%, p = 0.014). The low PG II group exhibited a higher incidence rate of GIM compared to the high PG II group (54.10% VS 44.44%, p = 0 0.020). In the Hp-negative(Hp-) group, there was a decrease in both PGI and PG II expression levels when compared to the Hp-positive(Hp+) group [146.73 ± 78.53 VS 125.61 ± 68.75 and 10.19(7.27, 16.58) VS 7.36(5.62,12.53), p = 0.036 and p < 0.001]. Among patients without Hp eradication history, those with low PG II levels had a higher proportion of individuals with a history of Hp eradication than those with high PG II levels (29.31% VS 3.13%, p = 0.003). Additionally, within the subgroup that underwent Hp eradication, there was a decrease in PG II expression level compared to the subgroup without Hp eradication (6.16(5.13, 7.52) VS 8.73(5.67, 13.35), p = 0.041). Conclusion The prevalence of GIM was significantly associated with low levels of PG II. There was a significant association between HP eradication history and the prevalence of GIM. Hp eradication history resulted in reduced expression levels of PG II in Hp- GIM patients.https://doi.org/10.1186/s41043-025-00756-yPepsinogenGastric mucosal intestinal metaplasiaOutpatientHelicobacter pylori eradication history |
| spellingShingle | Yanhong Wang Xixiang Cao Baodong Shan Song Chen Shengnan Li Sujuan Fei Xunlei Pang Hp eradication decreased the expression level of PG II in patients of Hp negative with gastric intestinal metaplasia: a retrospective cross-sectional study Journal of Health, Population and Nutrition Pepsinogen Gastric mucosal intestinal metaplasia Outpatient Helicobacter pylori eradication history |
| title | Hp eradication decreased the expression level of PG II in patients of Hp negative with gastric intestinal metaplasia: a retrospective cross-sectional study |
| title_full | Hp eradication decreased the expression level of PG II in patients of Hp negative with gastric intestinal metaplasia: a retrospective cross-sectional study |
| title_fullStr | Hp eradication decreased the expression level of PG II in patients of Hp negative with gastric intestinal metaplasia: a retrospective cross-sectional study |
| title_full_unstemmed | Hp eradication decreased the expression level of PG II in patients of Hp negative with gastric intestinal metaplasia: a retrospective cross-sectional study |
| title_short | Hp eradication decreased the expression level of PG II in patients of Hp negative with gastric intestinal metaplasia: a retrospective cross-sectional study |
| title_sort | hp eradication decreased the expression level of pg ii in patients of hp negative with gastric intestinal metaplasia a retrospective cross sectional study |
| topic | Pepsinogen Gastric mucosal intestinal metaplasia Outpatient Helicobacter pylori eradication history |
| url | https://doi.org/10.1186/s41043-025-00756-y |
| work_keys_str_mv | AT yanhongwang hperadicationdecreasedtheexpressionlevelofpgiiinpatientsofhpnegativewithgastricintestinalmetaplasiaaretrospectivecrosssectionalstudy AT xixiangcao hperadicationdecreasedtheexpressionlevelofpgiiinpatientsofhpnegativewithgastricintestinalmetaplasiaaretrospectivecrosssectionalstudy AT baodongshan hperadicationdecreasedtheexpressionlevelofpgiiinpatientsofhpnegativewithgastricintestinalmetaplasiaaretrospectivecrosssectionalstudy AT songchen hperadicationdecreasedtheexpressionlevelofpgiiinpatientsofhpnegativewithgastricintestinalmetaplasiaaretrospectivecrosssectionalstudy AT shengnanli hperadicationdecreasedtheexpressionlevelofpgiiinpatientsofhpnegativewithgastricintestinalmetaplasiaaretrospectivecrosssectionalstudy AT sujuanfei hperadicationdecreasedtheexpressionlevelofpgiiinpatientsofhpnegativewithgastricintestinalmetaplasiaaretrospectivecrosssectionalstudy AT xunleipang hperadicationdecreasedtheexpressionlevelofpgiiinpatientsofhpnegativewithgastricintestinalmetaplasiaaretrospectivecrosssectionalstudy |