Polycystin-1 regulates tendon-derived mesenchymal stem cells fate and matrix organization in heterotopic ossification

Abstract Mechanical stress modulates bone formation and organization of the extracellular matrix (ECM), the interaction of which affects heterotopic ossification (HO). However, the mechanically sensitive cell populations in HO and the underlying mechanism remain elusive. Here, we show that the mecha...

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Bibliographic Details
Main Authors: Yi Li Xu, Mei Huang, Yang Zhang, Xin Ying Su, Min Huang, Nan Yu Zou, Yu Rui Jiao, Yu Chen Sun, Ling Liu, Yong Hua Lei, Chang Jun Li
Format: Article
Language:English
Published: Nature Publishing Group 2025-01-01
Series:Bone Research
Online Access:https://doi.org/10.1038/s41413-024-00392-y
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