Diagnostic Role of Chromosomal Instability in Melanoma
Early diagnosis gives melanoma patients the best chance for long term survival. However discrimination of an early melanoma from an unusual/atypical benign nevus can represent a significant challenge. There are no current pathological markers to definitively define malignant potential in these indet...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Skin Cancer |
| Online Access: | http://dx.doi.org/10.1155/2012/914267 |
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| _version_ | 1832565167917891584 |
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| author | Nitika Dabas Diana M. Byrnes Ashley M. Rosa Mark S. Eller James M. Grichnik |
| author_facet | Nitika Dabas Diana M. Byrnes Ashley M. Rosa Mark S. Eller James M. Grichnik |
| author_sort | Nitika Dabas |
| collection | DOAJ |
| description | Early diagnosis gives melanoma patients the best chance for long term survival. However discrimination of an early melanoma from an unusual/atypical benign nevus can represent a significant challenge. There are no current pathological markers to definitively define malignant potential in these indeterminate lesions. Thus, there is a need for improved diagnostic tools. Chromosomal instability (CIN) is a hallmark of cancer and is markedly prevalent in melanoma. Advances in genomics have opened the door for the development of molecular tools to better segregate benign and malignant lesions. This paper focuses on CIN in melanoma and the role of current diagnostic approaches. |
| format | Article |
| id | doaj-art-62b8cf30460348e5915d1a31a00a3a5f |
| institution | Kabale University |
| issn | 2090-2905 2090-2913 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Skin Cancer |
| spelling | doaj-art-62b8cf30460348e5915d1a31a00a3a5f2025-02-03T01:08:59ZengWileyJournal of Skin Cancer2090-29052090-29132012-01-01201210.1155/2012/914267914267Diagnostic Role of Chromosomal Instability in MelanomaNitika Dabas0Diana M. Byrnes1Ashley M. Rosa2Mark S. Eller3James M. Grichnik4Department of Dermatology, Anna Fund Melanoma Program, Sylvester Comprehensive Cancer Center and Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Room 912, 1501 NW 10th Avenue, Miami, FL 33136-1012, USADepartment of Dermatology, Anna Fund Melanoma Program, Sylvester Comprehensive Cancer Center and Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Room 912, 1501 NW 10th Avenue, Miami, FL 33136-1012, USADepartment of Dermatology, Anna Fund Melanoma Program, Sylvester Comprehensive Cancer Center and Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Room 912, 1501 NW 10th Avenue, Miami, FL 33136-1012, USADepartment of Dermatology, Anna Fund Melanoma Program, Sylvester Comprehensive Cancer Center and Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Room 912, 1501 NW 10th Avenue, Miami, FL 33136-1012, USADepartment of Dermatology, Anna Fund Melanoma Program, Sylvester Comprehensive Cancer Center and Interdisciplinary Stem Cell Institute, Miller School of Medicine, University of Miami, Room 912, 1501 NW 10th Avenue, Miami, FL 33136-1012, USAEarly diagnosis gives melanoma patients the best chance for long term survival. However discrimination of an early melanoma from an unusual/atypical benign nevus can represent a significant challenge. There are no current pathological markers to definitively define malignant potential in these indeterminate lesions. Thus, there is a need for improved diagnostic tools. Chromosomal instability (CIN) is a hallmark of cancer and is markedly prevalent in melanoma. Advances in genomics have opened the door for the development of molecular tools to better segregate benign and malignant lesions. This paper focuses on CIN in melanoma and the role of current diagnostic approaches.http://dx.doi.org/10.1155/2012/914267 |
| spellingShingle | Nitika Dabas Diana M. Byrnes Ashley M. Rosa Mark S. Eller James M. Grichnik Diagnostic Role of Chromosomal Instability in Melanoma Journal of Skin Cancer |
| title | Diagnostic Role of Chromosomal Instability in Melanoma |
| title_full | Diagnostic Role of Chromosomal Instability in Melanoma |
| title_fullStr | Diagnostic Role of Chromosomal Instability in Melanoma |
| title_full_unstemmed | Diagnostic Role of Chromosomal Instability in Melanoma |
| title_short | Diagnostic Role of Chromosomal Instability in Melanoma |
| title_sort | diagnostic role of chromosomal instability in melanoma |
| url | http://dx.doi.org/10.1155/2012/914267 |
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