Excess of Aminopeptidase A in the Brain Elevates Blood Pressure via the Angiotensin II Type 1 and Bradykinin B2 Receptors without Dipsogenic Effect

Aminopeptidase A (APA) cleaves angiotensin (Ang) II, kallidin, and other related peptides. In the brain, it activates the renin angiotensin system and causes hypertension. Limited data are available on the dipsogenic effect of APA and pressor effect of degraded peptides of APA such as bradykinin. Wi...

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Bibliographic Details
Main Authors: Takuto Nakamura, Masanobu Yamazato, Akio Ishida, Yusuke Ohya
Format: Article
Language:English
Published: Wiley 2017-01-01
Series:International Journal of Hypertension
Online Access:http://dx.doi.org/10.1155/2017/3967595
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