Hydroxyapatite-ciprofloxacin delivery system: Synthesis, characterisation and antibacterial activity

Hydroxyapatite-ciprofloxacin delivery system: Synthesis, characterisation and antibacterial activity

The main objective of this study was to synthesize hydroxyapatite-ciprofloxacin composites using a chemical precipitation method and to evaluate the properties and in vitro release profile of the drug from the hydroxyapatite-ciprofloxacin composites. Composite characterization was achieved by FT-IR,...

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Main Authors: Ciocilteu Maria-Viorica, Mocanu Andreea Gabriela, Mocanu Adriana, Ducu Catalin, Nicolaescu Oana Elena, Manda Valentin Costel, Turcu-Stiolica Adina, Nicolicescu Claudiu, Melinte Razvan, Balasoiu Maria, Croitoru Octavian, Neamtu Johny
Format: Article
Language:English
Published: Sciendo 2018-06-01
Series:Acta Pharmaceutica
Subjects:
hydroxiapatite-ciprofloxacin composites
wet precipitation synthesis
in vitro release profile
antibacterial activity
Online Access:https://doi.org/10.2478/acph-2018-0011
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Summary:The main objective of this study was to synthesize hydroxyapatite-ciprofloxacin composites using a chemical precipitation method and to evaluate the properties and in vitro release profile of the drug from the hydroxyapatite-ciprofloxacin composites. Composite characterization was achieved by FT-IR, XRD and DLS. Ciprofloxacin determination was accomplished by HPLC, resulting in good incorporation efficiency of the drug (18.13 %). The in vitro release study (Higuchi model C = K t1/2 and Ritger-Peppas model, C = K t0.6) showed a diffusion-controlled mechanism. The antibacterial activity showed that the bacterial growth inhibition zones were approximately equal for the synthesis composites and for the mechanical mixture on the Staphylococcus aureus germ.
ISSN:1846-9558

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