Characterization of the genomic landscape in liver oligometastatic NSCLC
Abstract Objectives Emerging data have shown that local treatment could provide clinical benefit for non-small cell lung cancer (NSCLC) patients with oligometastasis. Liver metastases have the worst prognosis in advanced NSCLC, but the genomic characteristics of liver oligometastasis remain unclear....
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BMC
2025-01-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-025-13478-5 |
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| author | Rongxin Liao Guangming Yi Lu Shen Xiao Xiao Chuan Zeng Liangzhong Liu Hongjun Tang Shunping Huang Xiaoyue Zhang Zaicheng Xu Zhenzhou Yang Yuan Peng |
| author_facet | Rongxin Liao Guangming Yi Lu Shen Xiao Xiao Chuan Zeng Liangzhong Liu Hongjun Tang Shunping Huang Xiaoyue Zhang Zaicheng Xu Zhenzhou Yang Yuan Peng |
| author_sort | Rongxin Liao |
| collection | DOAJ |
| description | Abstract Objectives Emerging data have shown that local treatment could provide clinical benefit for non-small cell lung cancer (NSCLC) patients with oligometastasis. Liver metastases have the worst prognosis in advanced NSCLC, but the genomic characteristics of liver oligometastasis remain unclear. The aim of our study was to elucidate the molecular features of liver oligometastatic NSCLC. Methods Paired liver metastatic tissue samples and peripheral blood from 32 liver oligometastatic NSCLC patients were concurrently collected for comprehensive genomic analysis using next-generation sequencing. Results A total of 206 mutated genes in 32 patients were detected, with a median of 4 mutations per sample. The most frequent alterations (> 10%) in liver oligometastasis were TP53 (72%), EGFR (50%), RB1 (19%) and SMARCA4 (12%). The co-occurrence rate of TP53 and RB1 in our cohort was significantly higher than that in the TCGA-LUAD cohort. Age, APOBEC, homologous recombination deficiency (HRD) and deficient mismatch repair (dMMR) established the mutational signature of liver oligometastatic NSCLC. The median tumor mutation burden (TMB) was 4.8 mutations/Mb. A total of 78.12% patients harbored at least one potentially actionable molecular alteration that may guide further targeted therapy according to the OncoKB evidence. Conclusions Our study comprehensively delineated the genomic characteristics of liver oligometastatic NSCLC - such findings were helpful to better understand the distinct clinic-biological features of oligometastasis and optimize personalized treatment of this population. |
| format | Article |
| id | doaj-art-62236bf9c825480b96d50a3de9bf3f3b |
| institution | Kabale University |
| issn | 1471-2407 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj-art-62236bf9c825480b96d50a3de9bf3f3b2025-01-19T12:26:45ZengBMCBMC Cancer1471-24072025-01-0125111110.1186/s12885-025-13478-5Characterization of the genomic landscape in liver oligometastatic NSCLCRongxin Liao0Guangming Yi1Lu Shen2Xiao Xiao3Chuan Zeng4Liangzhong Liu5Hongjun Tang6Shunping Huang7Xiaoyue Zhang8Zaicheng Xu9Zhenzhou Yang10Yuan Peng11Department of Cancer Center, Second Affiliated Hospital, Chongqing Medical UniversityDepartment of Cancer Center, Second Affiliated Hospital, Chongqing Medical UniversityGeneplus-BeijingGeneplus-BeijingDepartment of Cancer Center, Second Affiliated Hospital, Chongqing Medical UniversityDepartment of Cancer Center, Second Affiliated Hospital, Chongqing Medical UniversityDepartment of Cancer Center, Second Affiliated Hospital, Chongqing Medical UniversityDepartment of Cancer Center, Second Affiliated Hospital, Chongqing Medical UniversityDepartment of Cancer Center, Second Affiliated Hospital, Chongqing Medical UniversityDepartment of Cancer Center, Second Affiliated Hospital, Chongqing Medical UniversityDepartment of Cancer Center, Second Affiliated Hospital, Chongqing Medical UniversityDepartment of Cancer Center, Second Affiliated Hospital, Chongqing Medical UniversityAbstract Objectives Emerging data have shown that local treatment could provide clinical benefit for non-small cell lung cancer (NSCLC) patients with oligometastasis. Liver metastases have the worst prognosis in advanced NSCLC, but the genomic characteristics of liver oligometastasis remain unclear. The aim of our study was to elucidate the molecular features of liver oligometastatic NSCLC. Methods Paired liver metastatic tissue samples and peripheral blood from 32 liver oligometastatic NSCLC patients were concurrently collected for comprehensive genomic analysis using next-generation sequencing. Results A total of 206 mutated genes in 32 patients were detected, with a median of 4 mutations per sample. The most frequent alterations (> 10%) in liver oligometastasis were TP53 (72%), EGFR (50%), RB1 (19%) and SMARCA4 (12%). The co-occurrence rate of TP53 and RB1 in our cohort was significantly higher than that in the TCGA-LUAD cohort. Age, APOBEC, homologous recombination deficiency (HRD) and deficient mismatch repair (dMMR) established the mutational signature of liver oligometastatic NSCLC. The median tumor mutation burden (TMB) was 4.8 mutations/Mb. A total of 78.12% patients harbored at least one potentially actionable molecular alteration that may guide further targeted therapy according to the OncoKB evidence. Conclusions Our study comprehensively delineated the genomic characteristics of liver oligometastatic NSCLC - such findings were helpful to better understand the distinct clinic-biological features of oligometastasis and optimize personalized treatment of this population.https://doi.org/10.1186/s12885-025-13478-5NSCLCLiver oligometastasisGenomic profilingNext-generation sequencingTumor mutational burden |
| spellingShingle | Rongxin Liao Guangming Yi Lu Shen Xiao Xiao Chuan Zeng Liangzhong Liu Hongjun Tang Shunping Huang Xiaoyue Zhang Zaicheng Xu Zhenzhou Yang Yuan Peng Characterization of the genomic landscape in liver oligometastatic NSCLC BMC Cancer NSCLC Liver oligometastasis Genomic profiling Next-generation sequencing Tumor mutational burden |
| title | Characterization of the genomic landscape in liver oligometastatic NSCLC |
| title_full | Characterization of the genomic landscape in liver oligometastatic NSCLC |
| title_fullStr | Characterization of the genomic landscape in liver oligometastatic NSCLC |
| title_full_unstemmed | Characterization of the genomic landscape in liver oligometastatic NSCLC |
| title_short | Characterization of the genomic landscape in liver oligometastatic NSCLC |
| title_sort | characterization of the genomic landscape in liver oligometastatic nsclc |
| topic | NSCLC Liver oligometastasis Genomic profiling Next-generation sequencing Tumor mutational burden |
| url | https://doi.org/10.1186/s12885-025-13478-5 |
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