Targeted drug delivery in neurodegenerative diseases: the role of nanotechnology
Neurodegenerative diseases, characterized by progressive neuronal loss and cognitive impairments, pose a significant global health challenge. This study explores the potential of nanotherapeutics as a promising approach to enhance drug delivery across physiological barriers, particularly the blood–b...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-01-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2025.1522223/full |
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| author | Rupal Dhariwal Rupal Dhariwal Mukul Jain Mukul Jain Yaser Rafiq Mir Abhayveer Singh Bhavik Jain Pankaj Kumar Mohd Tariq Mohd Tariq Devvret Verma Khemraj Deshmukh Virendra Kumar Yadav Tabarak Malik Tabarak Malik |
| author_facet | Rupal Dhariwal Rupal Dhariwal Mukul Jain Mukul Jain Yaser Rafiq Mir Abhayveer Singh Bhavik Jain Pankaj Kumar Mohd Tariq Mohd Tariq Devvret Verma Khemraj Deshmukh Virendra Kumar Yadav Tabarak Malik Tabarak Malik |
| author_sort | Rupal Dhariwal |
| collection | DOAJ |
| description | Neurodegenerative diseases, characterized by progressive neuronal loss and cognitive impairments, pose a significant global health challenge. This study explores the potential of nanotherapeutics as a promising approach to enhance drug delivery across physiological barriers, particularly the blood–brain barrier (BBB) and blood-cerebrospinal fluid barrier (B-CSFB). By employing nanoparticles, this research aims to address critical challenges in the diagnosis and treatment of conditions such as Alzheimer’s, Parkinson’s, and Huntington’s diseases. The multifactorial nature of these disorders necessitates innovative solutions that leverage nanomedicine to improve drug solubility, circulation time, and targeted delivery while minimizing off-target effects. The findings underscore the importance of advancing nanomedicine applications to develop effective therapeutic strategies that can alleviate the burden of neurodegenerative diseases on individuals and healthcare systems. |
| format | Article |
| id | doaj-art-621cdaf9f34e4caeb7d9cd44aa8720c2 |
| institution | Kabale University |
| issn | 2296-858X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj-art-621cdaf9f34e4caeb7d9cd44aa8720c22025-02-03T12:58:41ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-01-011210.3389/fmed.2025.15222231522223Targeted drug delivery in neurodegenerative diseases: the role of nanotechnologyRupal Dhariwal0Rupal Dhariwal1Mukul Jain2Mukul Jain3Yaser Rafiq Mir4Abhayveer Singh5Bhavik Jain6Pankaj Kumar7Mohd Tariq8Mohd Tariq9Devvret Verma10Khemraj Deshmukh11Virendra Kumar Yadav12Tabarak Malik13Tabarak Malik14Research and Development Cell, Parul University, Vadodara, IndiaDepartment of Life Sciences, Parul Institute of Applied Sciences, Parul University, Vadodara, IndiaResearch and Development Cell, Parul University, Vadodara, IndiaDepartment of Life Sciences, Parul Institute of Applied Sciences, Parul University, Vadodara, IndiaDepartment of Biotechnology, Baba Ghulam Shah Badshah University, Rajouri, IndiaCentre for Research Impact and Outcome, Chitkara University Institute of Engineering and Technology, Chitkara University, Rajpura, IndiaChitkara Centre for Research and Development, Chitkara University, Baddi, IndiaDepartment of Environmental Science, Parul Institute of Applied Sciences, Parul University, Vadodara, IndiaDepartment of Life Sciences, Parul Institute of Applied Sciences, Parul University, Vadodara, IndiaDepartment of Biotechnology, Graphic Era (Deemed to be University), Dehradun, IndiaDepartment of Biotechnology, Graphic Era (Deemed to be University), Dehradun, IndiaDepartment of Biomedical Engineering, Parul Institute of Technology, Parul University, Vadodara, IndiaMarwadi University Research Center, Marwadi University, Rajkot, India0Department of Biomedical Sciences, Institute of Health, Jimma University, Jimma, Ethiopia1Division of Research & Development, Lovely Professional University, Phagwara, Punjab, IndiaNeurodegenerative diseases, characterized by progressive neuronal loss and cognitive impairments, pose a significant global health challenge. This study explores the potential of nanotherapeutics as a promising approach to enhance drug delivery across physiological barriers, particularly the blood–brain barrier (BBB) and blood-cerebrospinal fluid barrier (B-CSFB). By employing nanoparticles, this research aims to address critical challenges in the diagnosis and treatment of conditions such as Alzheimer’s, Parkinson’s, and Huntington’s diseases. The multifactorial nature of these disorders necessitates innovative solutions that leverage nanomedicine to improve drug solubility, circulation time, and targeted delivery while minimizing off-target effects. The findings underscore the importance of advancing nanomedicine applications to develop effective therapeutic strategies that can alleviate the burden of neurodegenerative diseases on individuals and healthcare systems.https://www.frontiersin.org/articles/10.3389/fmed.2025.1522223/fullnanotherapeuticsneurodegenerationtargeted deliverysmall moleculesNeurodegenerative disease |
| spellingShingle | Rupal Dhariwal Rupal Dhariwal Mukul Jain Mukul Jain Yaser Rafiq Mir Abhayveer Singh Bhavik Jain Pankaj Kumar Mohd Tariq Mohd Tariq Devvret Verma Khemraj Deshmukh Virendra Kumar Yadav Tabarak Malik Tabarak Malik Targeted drug delivery in neurodegenerative diseases: the role of nanotechnology Frontiers in Medicine nanotherapeutics neurodegeneration targeted delivery small molecules Neurodegenerative disease |
| title | Targeted drug delivery in neurodegenerative diseases: the role of nanotechnology |
| title_full | Targeted drug delivery in neurodegenerative diseases: the role of nanotechnology |
| title_fullStr | Targeted drug delivery in neurodegenerative diseases: the role of nanotechnology |
| title_full_unstemmed | Targeted drug delivery in neurodegenerative diseases: the role of nanotechnology |
| title_short | Targeted drug delivery in neurodegenerative diseases: the role of nanotechnology |
| title_sort | targeted drug delivery in neurodegenerative diseases the role of nanotechnology |
| topic | nanotherapeutics neurodegeneration targeted delivery small molecules Neurodegenerative disease |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1522223/full |
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