Genetic deletion of microsomal prostaglandin E synthase-1 promotes imiquimod-induced psoriasis in mice

Genetic deletion of microsomal prostaglandin E synthase-1 promotes imiquimod-induced psoriasis in mice

Abstract Background Psoriasis is a chronic inflammatory disease associated with abnormalities in the immune system. Microsomal prostaglandin E synthase-1 (mPGES-1), a terminal enzyme for prostaglandin (PG) E2 biosynthesis, is highly expressed in the skin of psoriasis patients. However, the detailed...

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Main Authors: Fumiaki Kojima, Yuka Hioki, Miori Sumida, Yoshiko Iizuka, Hitoshi Kashiwagi, Kei Eto, Shiho Arichi, Shotaro Maehana, Makoto Kubo, Haruhito A. Uchida, Takafumi Ichikawa
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Inflammation and Regeneration
Subjects:
Psoriasis
Inflammation
Immunity
Interleukin-17 A
Cyclooxygenase
Prostaglandin E synthase
Online Access:https://doi.org/10.1186/s41232-025-00385-2
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https://doi.org/10.1186/s41232-025-00385-2

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