Anticoagulation strategies for pediatric continuous renal replacement therapy
Continuous renal replacement therapy (CRRT) in children is quite challenging to manage because of their increased propensity for circuit clotting. The anticoagulant strategies are paramount in reducing the downtime in pediatric CRRT. The most commonly used anticoagulants in pediatrics are unfraction...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-09-01
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| Series: | Journal of Pediatric Critical Care |
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| Online Access: | https://journals.lww.com/10.4103/jpcc.jpcc_63_24 |
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| author | Aakash Chandran Chidambaram Ankit Mangla Karthi Nallasamy |
| author_facet | Aakash Chandran Chidambaram Ankit Mangla Karthi Nallasamy |
| author_sort | Aakash Chandran Chidambaram |
| collection | DOAJ |
| description | Continuous renal replacement therapy (CRRT) in children is quite challenging to manage because of their increased propensity for circuit clotting. The anticoagulant strategies are paramount in reducing the downtime in pediatric CRRT. The most commonly used anticoagulants in pediatrics are unfractionated heparin and citrate anticoagulation. The other less explored options include regional heparin protamine anticoagulation, prostacyclin, low-molecular-weight heparin, and thrombin antagonists. The choice of anticoagulant primarily depends on the patient’s condition, availability and cost of the anticoagulant, potential side effects, and the local expertise for troubleshooting. This article aims to bring about the merits and demerits of the different anticoagulants available for CRRT and the available evidence for the use of each of these anticoagulants. |
| format | Article |
| id | doaj-art-61f5ce1a5b7541ca838d0dea2ecea013 |
| institution | Kabale University |
| issn | 2349-6592 2455-7099 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Pediatric Critical Care |
| spelling | doaj-art-61f5ce1a5b7541ca838d0dea2ecea0132025-01-23T06:03:35ZengWolters Kluwer Medknow PublicationsJournal of Pediatric Critical Care2349-65922455-70992024-09-0111521822610.4103/jpcc.jpcc_63_24Anticoagulation strategies for pediatric continuous renal replacement therapyAakash Chandran ChidambaramAnkit ManglaKarthi NallasamyContinuous renal replacement therapy (CRRT) in children is quite challenging to manage because of their increased propensity for circuit clotting. The anticoagulant strategies are paramount in reducing the downtime in pediatric CRRT. The most commonly used anticoagulants in pediatrics are unfractionated heparin and citrate anticoagulation. The other less explored options include regional heparin protamine anticoagulation, prostacyclin, low-molecular-weight heparin, and thrombin antagonists. The choice of anticoagulant primarily depends on the patient’s condition, availability and cost of the anticoagulant, potential side effects, and the local expertise for troubleshooting. This article aims to bring about the merits and demerits of the different anticoagulants available for CRRT and the available evidence for the use of each of these anticoagulants.https://journals.lww.com/10.4103/jpcc.jpcc_63_24anticoagulationcontinuous renal replacement therapyprostacyclinregional citrate anticoagulationunfractionated heparin |
| spellingShingle | Aakash Chandran Chidambaram Ankit Mangla Karthi Nallasamy Anticoagulation strategies for pediatric continuous renal replacement therapy Journal of Pediatric Critical Care anticoagulation continuous renal replacement therapy prostacyclin regional citrate anticoagulation unfractionated heparin |
| title | Anticoagulation strategies for pediatric continuous renal replacement therapy |
| title_full | Anticoagulation strategies for pediatric continuous renal replacement therapy |
| title_fullStr | Anticoagulation strategies for pediatric continuous renal replacement therapy |
| title_full_unstemmed | Anticoagulation strategies for pediatric continuous renal replacement therapy |
| title_short | Anticoagulation strategies for pediatric continuous renal replacement therapy |
| title_sort | anticoagulation strategies for pediatric continuous renal replacement therapy |
| topic | anticoagulation continuous renal replacement therapy prostacyclin regional citrate anticoagulation unfractionated heparin |
| url | https://journals.lww.com/10.4103/jpcc.jpcc_63_24 |
| work_keys_str_mv | AT aakashchandranchidambaram anticoagulationstrategiesforpediatriccontinuousrenalreplacementtherapy AT ankitmangla anticoagulationstrategiesforpediatriccontinuousrenalreplacementtherapy AT karthinallasamy anticoagulationstrategiesforpediatriccontinuousrenalreplacementtherapy |