Zerumbone Attenuates the Severity of Acute Necrotizing Pancreatitis and Pancreatitis-Induced Hepatic Injury
This paper investigated the potential effects of zerumbone pretreatment on an acute necrotizing pancreatitis rat model induced by sodium taurocholate. The pancreatitis injury was evaluated by serum AMY, sPLA2, and pancreatic pathological score. Pancreatitis-induced hepatic injury was measured by ALT...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2012/156507 |
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| _version_ | 1832565384353415168 |
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| author | Deng Wenhong Yu Jia Wang Weixing Chen Xiaoyan Chen Chen Xu Sheng Jin Hao |
| author_facet | Deng Wenhong Yu Jia Wang Weixing Chen Xiaoyan Chen Chen Xu Sheng Jin Hao |
| author_sort | Deng Wenhong |
| collection | DOAJ |
| description | This paper investigated the potential effects of zerumbone pretreatment on an acute necrotizing pancreatitis rat model induced by sodium taurocholate. The pancreatitis injury was evaluated by serum AMY, sPLA2, and pancreatic pathological score. Pancreatitis-induced hepatic injury was measured by ALT, AST, and hepatic histopathology. The expression of I-κBα and NF-κB protein was evaluated by western blot and immunohistochemistry assay while ICAM-1 and IL-1β mRNA were examined by RT-PCR. The results showed that AMY, sPLA2, ALT, and AST levels and histopathological assay of pancreatic and hepatic tissues were significantly reduced following administration of zerumbone. Applying zerumbone also has been shown to inhibit NF-κB protein and downregulation of ICAM-1 and IL-1β mRNA. The present paper suggests that treatment of zerumbone on rat attenuates the severity of acute necrotizing pancreatitis and pancreatitis-induced hepatic injury, via inhibiting NF-κB activation and downregulating the expression of ICAM-1 and IL-1β. |
| format | Article |
| id | doaj-art-61c5f9a2935d495d8929b07c9560d52a |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-61c5f9a2935d495d8929b07c9560d52a2025-02-03T01:07:54ZengWileyMediators of Inflammation0962-93511466-18612012-01-01201210.1155/2012/156507156507Zerumbone Attenuates the Severity of Acute Necrotizing Pancreatitis and Pancreatitis-Induced Hepatic InjuryDeng Wenhong0Yu Jia1Wang Weixing2Chen Xiaoyan3Chen Chen4Xu Sheng5Jin Hao6Department of General Surgery, Renmin Hospital of Wuhan University, Hubei 430060, ChinaDepartment of General Surgery, Renmin Hospital of Wuhan University, Hubei 430060, ChinaDepartment of General Surgery, Renmin Hospital of Wuhan University, Hubei 430060, ChinaDepartment of General Surgery, Renmin Hospital of Wuhan University, Hubei 430060, ChinaDepartment of General Surgery, Renmin Hospital of Wuhan University, Hubei 430060, ChinaDepartment of General Surgery, People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning 530000, ChinaDepartment of General Surgery, Renmin Hospital of Wuhan University, Hubei 430060, ChinaThis paper investigated the potential effects of zerumbone pretreatment on an acute necrotizing pancreatitis rat model induced by sodium taurocholate. The pancreatitis injury was evaluated by serum AMY, sPLA2, and pancreatic pathological score. Pancreatitis-induced hepatic injury was measured by ALT, AST, and hepatic histopathology. The expression of I-κBα and NF-κB protein was evaluated by western blot and immunohistochemistry assay while ICAM-1 and IL-1β mRNA were examined by RT-PCR. The results showed that AMY, sPLA2, ALT, and AST levels and histopathological assay of pancreatic and hepatic tissues were significantly reduced following administration of zerumbone. Applying zerumbone also has been shown to inhibit NF-κB protein and downregulation of ICAM-1 and IL-1β mRNA. The present paper suggests that treatment of zerumbone on rat attenuates the severity of acute necrotizing pancreatitis and pancreatitis-induced hepatic injury, via inhibiting NF-κB activation and downregulating the expression of ICAM-1 and IL-1β.http://dx.doi.org/10.1155/2012/156507 |
| spellingShingle | Deng Wenhong Yu Jia Wang Weixing Chen Xiaoyan Chen Chen Xu Sheng Jin Hao Zerumbone Attenuates the Severity of Acute Necrotizing Pancreatitis and Pancreatitis-Induced Hepatic Injury Mediators of Inflammation |
| title | Zerumbone Attenuates the Severity of Acute Necrotizing Pancreatitis and Pancreatitis-Induced Hepatic Injury |
| title_full | Zerumbone Attenuates the Severity of Acute Necrotizing Pancreatitis and Pancreatitis-Induced Hepatic Injury |
| title_fullStr | Zerumbone Attenuates the Severity of Acute Necrotizing Pancreatitis and Pancreatitis-Induced Hepatic Injury |
| title_full_unstemmed | Zerumbone Attenuates the Severity of Acute Necrotizing Pancreatitis and Pancreatitis-Induced Hepatic Injury |
| title_short | Zerumbone Attenuates the Severity of Acute Necrotizing Pancreatitis and Pancreatitis-Induced Hepatic Injury |
| title_sort | zerumbone attenuates the severity of acute necrotizing pancreatitis and pancreatitis induced hepatic injury |
| url | http://dx.doi.org/10.1155/2012/156507 |
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