Domperidone inhibits dengue virus infection by targeting the viral envelope protein and nonstructural protein 1

Domperidone inhibits dengue virus infection by targeting the viral envelope protein and nonstructural protein 1

Abstract Dengue is a mosquito-borne disease caused by dengue virus (DENV) infection, which remains a major public health concern worldwide owing to the lack of specific treatments or antiviral drugs available. This study investigated the potential repurposing of domperidone, an antiemetic and gastro...

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Main Authors: Nuttapong Kaewjiw, Thanawat Thaingtamtanha, Damini Mehra, Wanida Chawnawa, Tanapan Prommool, Chunya Puttikhunt, Adisak Songjaeng, Kessiri Kongmanas, Panisadee Avirutnan, Prasit Luangaram, Chatchawan Srisawat, Sittiruk Roytrakul, Stephan A. Bäurle, Sansanee Noisakran
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Scientific Reports
Subjects:
Dengue virus
Domperidone
MD simulation
E and NS1 proteins
DENV production
NS1 secretion
Online Access:https://doi.org/10.1038/s41598-025-87146-w
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