Epstein-Barr virus evades CD4+ T cell responses in lytic cycle through BZLF1-mediated downregulation of CD74 and the cooperation of vBcl-2.

Epstein-Barr virus evades CD4+ T cell responses in lytic cycle through BZLF1-mediated downregulation of CD74 and the cooperation of vBcl-2.

Evasion of immune T cell responses is crucial for viruses to establish persistence in the infected host. Immune evasion mechanisms of Epstein-Barr virus (EBV) in the context of MHC-I antigen presentation have been well studied. In contrast, viral interference with MHC-II antigen presentation is less...

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Main Authors: Jianmin Zuo, Wendy A Thomas, Tracey A Haigh, Leah Fitzsimmons, Heather M Long, Andrew D Hislop, Graham S Taylor, Martin Rowe
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-12-01
Series:PLoS Pathogens
Online Access:https://journals.plos.org/plospathogens/article/file?id=10.1371/journal.ppat.1002455&type=printable
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