Cyclooxygenase-2/prostaglandin E2 pathway orchestrates the replication of infectious bronchitis virus in chicken tracheal explants

Cyclooxygenase-2/prostaglandin E2 pathway orchestrates the replication of infectious bronchitis virus in chicken tracheal explants

ABSTRACT In this study, we investigated the localized pathogenesis of infectious bronchitis virus (IBV) in chicken tracheal organ cultures (TOCs), focusing on the role of inducible cyclooxygenase (COX-2). Two divergent IBV strains, respiratory Connecticut (Conn) A5968 and nephropathogenic Delmarva (...

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Main Authors: Motamed Elsayed Mahmoud, Ahmed Ali, Muhammad Farooq, Ishara M. Isham, Sufna M. Suhail, Heshanthi Herath-Mudiyanselage, Ryan Rahimi, Mohamed Faizal Abdul-Careem
Format: Article
Language:English
Published: American Society for Microbiology 2024-12-01
Series:Microbiology Spectrum
Subjects:
infectious bronchitis virus
tracheal organ culture
cyclooxygenase 2
prostaglandin E2
selective cyclooxygenase-2 inhibitor
prostaglandin receptor antagonists
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00407-24
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https://journals.asm.org/doi/10.1128/spectrum.00407-24

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