Development of a Heuristic Machine Analogy Method for Model Simplification With an Application to a Large‐Scale Model of Gi/Gs Signaling

ABSTRACT Model simplification is a process to simplify large‐scale mathematical models to enable easy applications such as simulation and parameter estimation. A novel heuristic machine analogy method of model simplification was developed and applied to a motivating example of a model for cAMP signa...

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Bibliographic Details
Main Authors: Liang Yang, David Finlay, Michelle Glass, Stephen Duffull
Format: Article
Language:English
Published: Wiley 2025-06-01
Series:CPT: Pharmacometrics & Systems Pharmacology
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Online Access:https://doi.org/10.1002/psp4.70029
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