Depression-induced changes in directed functional brain networks: A source-space resting-state EEG study
Current research confirms abnormalities in resting-state electroencephalogram (EEG) power and functional connectivity (FC) patterns in specific brain regions of individuals with depression. To study changes in the flow of information between cortical regions of the brain in patients with depression,...
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| Format: | Article |
| Language: | English |
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AIMS Press
2024-09-01
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| Series: | Mathematical Biosciences and Engineering |
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| Online Access: | https://www.aimspress.com/article/doi/10.3934/mbe.2024315 |
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| _version_ | 1832590815926419456 |
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| author | Zhongwen Jia Lihan Tang Jidong Lv Linhong Deng Ling Zou |
| author_facet | Zhongwen Jia Lihan Tang Jidong Lv Linhong Deng Ling Zou |
| author_sort | Zhongwen Jia |
| collection | DOAJ |
| description | Current research confirms abnormalities in resting-state electroencephalogram (EEG) power and functional connectivity (FC) patterns in specific brain regions of individuals with depression. To study changes in the flow of information between cortical regions of the brain in patients with depression, we used 64-channel EEG to record neural oscillatory activity in 68 relevant cortical regions in 22 depressed patients and 22 healthy adolescents using source-space EEG. The direction and strength of information flow between brain regions was investigated using directional phase transfer entropy (PTE). Compared to healthy controls, we observed an increased intensity of PTE information flow between the left and right hemispheres in the theta and alpha frequency bands in depressed subjects. The intensity of information flow between anterior and posterior regions within each hemisphere was reduced. Significant differences were found in the left supramarginal gyrus, right delta in the theta frequency band and bilateral lateral occipital lobe, and paracentral gyrus and parahippocampal gyrus in the alpha frequency band. The accuracy of cross-classification of directed PTE values with significant differences between groups was 91%. These findings suggest that altered information flow in the brains of depressed patients is related to the pathogenesis of depression, providing insights for patient identification and pathological studies. |
| format | Article |
| id | doaj-art-61584af7f1f94c90adf414a8d2e41134 |
| institution | Kabale University |
| issn | 1551-0018 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | AIMS Press |
| record_format | Article |
| series | Mathematical Biosciences and Engineering |
| spelling | doaj-art-61584af7f1f94c90adf414a8d2e411342025-01-23T07:47:53ZengAIMS PressMathematical Biosciences and Engineering1551-00182024-09-012197124713810.3934/mbe.2024315Depression-induced changes in directed functional brain networks: A source-space resting-state EEG studyZhongwen Jia0Lihan Tang1Jidong Lv2Linhong Deng3Ling Zou4School of Microelectronics and Control Engineering, Changzhou University, Jiangsu 213164, ChinaSchool of Microelectronics and Control Engineering, Changzhou University, Jiangsu 213164, ChinaSchool of Microelectronics and Control Engineering, Changzhou University, Jiangsu 213164, ChinaInstitute of Biomedical Engineering and Health Sciences, Changzhou University, Jiangsu 213164, ChinaSchool of Microelectronics and Control Engineering, Changzhou University, Jiangsu 213164, ChinaCurrent research confirms abnormalities in resting-state electroencephalogram (EEG) power and functional connectivity (FC) patterns in specific brain regions of individuals with depression. To study changes in the flow of information between cortical regions of the brain in patients with depression, we used 64-channel EEG to record neural oscillatory activity in 68 relevant cortical regions in 22 depressed patients and 22 healthy adolescents using source-space EEG. The direction and strength of information flow between brain regions was investigated using directional phase transfer entropy (PTE). Compared to healthy controls, we observed an increased intensity of PTE information flow between the left and right hemispheres in the theta and alpha frequency bands in depressed subjects. The intensity of information flow between anterior and posterior regions within each hemisphere was reduced. Significant differences were found in the left supramarginal gyrus, right delta in the theta frequency band and bilateral lateral occipital lobe, and paracentral gyrus and parahippocampal gyrus in the alpha frequency band. The accuracy of cross-classification of directed PTE values with significant differences between groups was 91%. These findings suggest that altered information flow in the brains of depressed patients is related to the pathogenesis of depression, providing insights for patient identification and pathological studies.https://www.aimspress.com/article/doi/10.3934/mbe.2024315depressionelectroencephalogramdirected connectivitydepressive symptoms |
| spellingShingle | Zhongwen Jia Lihan Tang Jidong Lv Linhong Deng Ling Zou Depression-induced changes in directed functional brain networks: A source-space resting-state EEG study Mathematical Biosciences and Engineering depression electroencephalogram directed connectivity depressive symptoms |
| title | Depression-induced changes in directed functional brain networks: A source-space resting-state EEG study |
| title_full | Depression-induced changes in directed functional brain networks: A source-space resting-state EEG study |
| title_fullStr | Depression-induced changes in directed functional brain networks: A source-space resting-state EEG study |
| title_full_unstemmed | Depression-induced changes in directed functional brain networks: A source-space resting-state EEG study |
| title_short | Depression-induced changes in directed functional brain networks: A source-space resting-state EEG study |
| title_sort | depression induced changes in directed functional brain networks a source space resting state eeg study |
| topic | depression electroencephalogram directed connectivity depressive symptoms |
| url | https://www.aimspress.com/article/doi/10.3934/mbe.2024315 |
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