Effect of ADH II Deficiency on the Intracellular Redox Homeostasis in Zymomonas mobilis
Mutant strain of the facultatively anaerobic, ethanol-producing bacterium Zymomonas mobilis, deficient in the Fe-containing alcohol dehydrogenase isoenzyme (ADH II), showed impaired homeostasis of the intracellular NAD(P)H during transition from anaerobic to aerobic conditions, and also in steady-st...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
|
| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/742610 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832562604991578112 |
|---|---|
| author | Nina Galinina Zane Lasa Inese Strazdina Reinis Rutkis Uldis Kalnenieks |
| author_facet | Nina Galinina Zane Lasa Inese Strazdina Reinis Rutkis Uldis Kalnenieks |
| author_sort | Nina Galinina |
| collection | DOAJ |
| description | Mutant strain of the facultatively anaerobic, ethanol-producing bacterium Zymomonas mobilis, deficient in the Fe-containing alcohol dehydrogenase isoenzyme (ADH II), showed impaired homeostasis of the intracellular NAD(P)H during transition from anaerobic to aerobic conditions, and also in steady-state continuous cultures at various oxygen supplies. At the same time, ADH II deficiency in aerobically grown cells was accompanied by a threefold increase of catalase activity and by about 50% increase of hydrogen peroxide excretion. It is concluded that ADH II under aerobic conditions functions to maintain intracellular redox homeostasis and to protect the cells from endogenous hydrogen peroxide. |
| format | Article |
| id | doaj-art-613ee98b79c1480587c13f358e014612 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-613ee98b79c1480587c13f358e0146122025-02-03T01:22:14ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/742610742610Effect of ADH II Deficiency on the Intracellular Redox Homeostasis in Zymomonas mobilisNina Galinina0Zane Lasa1Inese Strazdina2Reinis Rutkis3Uldis Kalnenieks4Institute of Microbiology and Biotechnology, University of Latvia, Kronvalda Boulevard 4, 1586 Riga, LatviaInstitute of Microbiology and Biotechnology, University of Latvia, Kronvalda Boulevard 4, 1586 Riga, LatviaInstitute of Microbiology and Biotechnology, University of Latvia, Kronvalda Boulevard 4, 1586 Riga, LatviaInstitute of Microbiology and Biotechnology, University of Latvia, Kronvalda Boulevard 4, 1586 Riga, LatviaInstitute of Microbiology and Biotechnology, University of Latvia, Kronvalda Boulevard 4, 1586 Riga, LatviaMutant strain of the facultatively anaerobic, ethanol-producing bacterium Zymomonas mobilis, deficient in the Fe-containing alcohol dehydrogenase isoenzyme (ADH II), showed impaired homeostasis of the intracellular NAD(P)H during transition from anaerobic to aerobic conditions, and also in steady-state continuous cultures at various oxygen supplies. At the same time, ADH II deficiency in aerobically grown cells was accompanied by a threefold increase of catalase activity and by about 50% increase of hydrogen peroxide excretion. It is concluded that ADH II under aerobic conditions functions to maintain intracellular redox homeostasis and to protect the cells from endogenous hydrogen peroxide.http://dx.doi.org/10.1100/2012/742610 |
| spellingShingle | Nina Galinina Zane Lasa Inese Strazdina Reinis Rutkis Uldis Kalnenieks Effect of ADH II Deficiency on the Intracellular Redox Homeostasis in Zymomonas mobilis The Scientific World Journal |
| title | Effect of ADH II Deficiency on the Intracellular Redox Homeostasis in Zymomonas mobilis |
| title_full | Effect of ADH II Deficiency on the Intracellular Redox Homeostasis in Zymomonas mobilis |
| title_fullStr | Effect of ADH II Deficiency on the Intracellular Redox Homeostasis in Zymomonas mobilis |
| title_full_unstemmed | Effect of ADH II Deficiency on the Intracellular Redox Homeostasis in Zymomonas mobilis |
| title_short | Effect of ADH II Deficiency on the Intracellular Redox Homeostasis in Zymomonas mobilis |
| title_sort | effect of adh ii deficiency on the intracellular redox homeostasis in zymomonas mobilis |
| url | http://dx.doi.org/10.1100/2012/742610 |
| work_keys_str_mv | AT ninagalinina effectofadhiideficiencyontheintracellularredoxhomeostasisinzymomonasmobilis AT zanelasa effectofadhiideficiencyontheintracellularredoxhomeostasisinzymomonasmobilis AT inesestrazdina effectofadhiideficiencyontheintracellularredoxhomeostasisinzymomonasmobilis AT reinisrutkis effectofadhiideficiencyontheintracellularredoxhomeostasisinzymomonasmobilis AT uldiskalnenieks effectofadhiideficiencyontheintracellularredoxhomeostasisinzymomonasmobilis |