Genetic variation in IL-4 activated tissue resident macrophages determines strain-specific synergistic responses to LPS epigenetically

Genetic variation in IL-4 activated tissue resident macrophages determines strain-specific synergistic responses to LPS epigenetically

Abstract How macrophages in the tissue environment integrate multiple stimuli depends on the genetic background of the host, but this is still poorly understood. We investigate IL-4 activation of male C57BL/6 and BALB/c strain specific in vivo tissue-resident macrophages (TRMs) from the peritoneal c...

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Main Authors: Mingming Zhao, Dragana Jankovic, Verena M. Link, Camila Oliveira Silva Souza, Katherine M. Hornick, Oyebola Oyesola, Yasmine Belkaid, Justin Lack, Png Loke
Format: Article
Language:English
Published: Nature Portfolio 2025-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56379-8
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https://doi.org/10.1038/s41467-025-56379-8

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