Factors influencing lateral margin diagnosis challenges in Barrett’s esophageal cancer: a bicenter retrospective study in Japan
Background/Aims We aimed to clarify the clinicopathological characteristics and causes of Barrett’s esophageal adenocarcinoma (BEA) with unclear demarcation. Methods We reviewed BEA cases between January 2010 and August 2022. The lesions were classified into the following two groups: clear demarcati...
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| Format: | Article |
| Language: | English |
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Korean Society of Gastrointestinal Endoscopy
2025-01-01
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| Series: | Clinical Endoscopy |
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| Online Access: | http://www.e-ce.org/upload/pdf/ce-2024-068.pdf |
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| author | Ippei Tanaka Shuhei Unno Kazuki Yamamoto Yoshitaka Nawata Kimihiro Igarashi Tomoki Matsuda Dai Hirasawa |
| author_facet | Ippei Tanaka Shuhei Unno Kazuki Yamamoto Yoshitaka Nawata Kimihiro Igarashi Tomoki Matsuda Dai Hirasawa |
| author_sort | Ippei Tanaka |
| collection | DOAJ |
| description | Background/Aims We aimed to clarify the clinicopathological characteristics and causes of Barrett’s esophageal adenocarcinoma (BEA) with unclear demarcation. Methods We reviewed BEA cases between January 2010 and August 2022. The lesions were classified into the following two groups: clear demarcation (CD group) and unclear demarcation (UD group). We compared the clinicopathological findings between the two groups. Furthermore, we measured the length and width of the foveolar structures, as well as the width of marginal crypt epithelium (MCE). Results We analyzed data from 68 patients with BEA, including 47 and 21 in the CD and UD groups, respectively. Multivariate analysis revealed long-segment Barrett’s esophagus (LSBE) as the sole significant risk factor for BEA (odds ratio, 12.17; 95% confidence interval, 2.84–47.6; p=0.001). Regarding pathological analysis, significant differences were observed in the length and width of the foveolar structure between cancerous and surrounding mucosa in the CD group (p=0.03 and p=0.00, respectively); however, no significant difference was observed in the UD group (p=0.53 and p=0.72, respectively). Nevertheless, the width of MCE in the cancerous area was significantly shorter than that in the surrounding mucosa in both groups (all, p<0.05). Conclusions LSBE is a significant risk factor for BEA in the UD group. The width of MCE may be an important factor in the endoscopic diagnosis of BEA. |
| format | Article |
| id | doaj-art-61304422c9ca4ec2b3cda232ce1444b5 |
| institution | Kabale University |
| issn | 2234-2400 2234-2443 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Korean Society of Gastrointestinal Endoscopy |
| record_format | Article |
| series | Clinical Endoscopy |
| spelling | doaj-art-61304422c9ca4ec2b3cda232ce1444b52025-02-03T08:08:03ZengKorean Society of Gastrointestinal EndoscopyClinical Endoscopy2234-24002234-24432025-01-01581859310.5946/ce.2024.0687926Factors influencing lateral margin diagnosis challenges in Barrett’s esophageal cancer: a bicenter retrospective study in JapanIppei Tanaka0Shuhei Unno1Kazuki Yamamoto2Yoshitaka Nawata3Kimihiro Igarashi4Tomoki Matsuda5Dai Hirasawa6 Department of Gastroenterology, Sendai Kousei Hospital, Miyagi, Japan Department of Gastroenterology, Seirei Hamamatsu General Hospital, Shizuoka, Japan Digestive Diseases Center, Showa University Koto Toyosu Hospital, Tokyo, Japan Department of Gastroenterology, Sendai Kousei Hospital, Miyagi, Japan Department of Gastroenterology, Sendai Kousei Hospital, Miyagi, Japan Department of Gastroenterology, Sendai Kousei Hospital, Miyagi, Japan Department of Gastroenterology, Sendai Kousei Hospital, Miyagi, JapanBackground/Aims We aimed to clarify the clinicopathological characteristics and causes of Barrett’s esophageal adenocarcinoma (BEA) with unclear demarcation. Methods We reviewed BEA cases between January 2010 and August 2022. The lesions were classified into the following two groups: clear demarcation (CD group) and unclear demarcation (UD group). We compared the clinicopathological findings between the two groups. Furthermore, we measured the length and width of the foveolar structures, as well as the width of marginal crypt epithelium (MCE). Results We analyzed data from 68 patients with BEA, including 47 and 21 in the CD and UD groups, respectively. Multivariate analysis revealed long-segment Barrett’s esophagus (LSBE) as the sole significant risk factor for BEA (odds ratio, 12.17; 95% confidence interval, 2.84–47.6; p=0.001). Regarding pathological analysis, significant differences were observed in the length and width of the foveolar structure between cancerous and surrounding mucosa in the CD group (p=0.03 and p=0.00, respectively); however, no significant difference was observed in the UD group (p=0.53 and p=0.72, respectively). Nevertheless, the width of MCE in the cancerous area was significantly shorter than that in the surrounding mucosa in both groups (all, p<0.05). Conclusions LSBE is a significant risk factor for BEA in the UD group. The width of MCE may be an important factor in the endoscopic diagnosis of BEA.http://www.e-ce.org/upload/pdf/ce-2024-068.pdfbarrett’s esophagusendoscopic diagnosisesophageal cancer |
| spellingShingle | Ippei Tanaka Shuhei Unno Kazuki Yamamoto Yoshitaka Nawata Kimihiro Igarashi Tomoki Matsuda Dai Hirasawa Factors influencing lateral margin diagnosis challenges in Barrett’s esophageal cancer: a bicenter retrospective study in Japan Clinical Endoscopy barrett’s esophagus endoscopic diagnosis esophageal cancer |
| title | Factors influencing lateral margin diagnosis challenges in Barrett’s esophageal cancer: a bicenter retrospective study in Japan |
| title_full | Factors influencing lateral margin diagnosis challenges in Barrett’s esophageal cancer: a bicenter retrospective study in Japan |
| title_fullStr | Factors influencing lateral margin diagnosis challenges in Barrett’s esophageal cancer: a bicenter retrospective study in Japan |
| title_full_unstemmed | Factors influencing lateral margin diagnosis challenges in Barrett’s esophageal cancer: a bicenter retrospective study in Japan |
| title_short | Factors influencing lateral margin diagnosis challenges in Barrett’s esophageal cancer: a bicenter retrospective study in Japan |
| title_sort | factors influencing lateral margin diagnosis challenges in barrett s esophageal cancer a bicenter retrospective study in japan |
| topic | barrett’s esophagus endoscopic diagnosis esophageal cancer |
| url | http://www.e-ce.org/upload/pdf/ce-2024-068.pdf |
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