Uncovering the Phytochemical Profile, Antioxidant Potency, Anti-Inflammatory Effects, and Thrombolytic Activity in Dendrobium lindleyi Steud.
Background. Dendrobium genus has been used in traditional medicine to treat various illnesses. The study aims at examining the phytochemical, antioxidant, anti-inflammatory, and thrombolytic properties of the leaf, stem, and root of Dendrobium lindleyi Steud, and the relationship between phytochemic...
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| Format: | Article |
| Language: | English |
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Wiley
2023-01-01
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| Series: | Scientifica |
| Online Access: | http://dx.doi.org/10.1155/2023/9999640 |
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| author | Minhajur Rahman Roxy Begum Abu Taleb Surag Md. Shakhuat Hossain Tusher Mohammed Kamrul Huda |
| author_facet | Minhajur Rahman Roxy Begum Abu Taleb Surag Md. Shakhuat Hossain Tusher Mohammed Kamrul Huda |
| author_sort | Minhajur Rahman |
| collection | DOAJ |
| description | Background. Dendrobium genus has been used in traditional medicine to treat various illnesses. The study aims at examining the phytochemical, antioxidant, anti-inflammatory, and thrombolytic properties of the leaf, stem, and root of Dendrobium lindleyi Steud, and the relationship between phytochemicals and bioactivities is determined. Results. The qualitative screening found a variety of bioactive compounds, including alkaloids, coumarins, cardiac glycosides, glycosides, flavonoids, proteins, phenols, quinines, resins, steroids, saponins, tannins, and terpenoids, in varying amounts. The quantitative screening showed the highest concentration of alkaloids in the leaves (172.15 ± 1.22 mg/g), phenols in the root (203.55 ± 0.75 mg/g), flavonoids in the root (24.35 ± 0.42 mg/g), tannins in the leaves (105.06 ± 0.55 mg/g), and proteins in the root (194.12 ± 0.65 µg/ml). The root extract showed the highest antioxidant activity (IC50 = 58.24 µg/mL), the stem extract had the most increased thrombolytic activity (IC50 = 242.74 µg/mL), and the leaf extract had the most potent anti-inflammatory activity (IC50 = 61.79 µg/mL). Statistical analysis revealed a significant positive relationship (p=0.05) between alkaloids (r = 0.96) and tannins (r = 0.9) with antioxidant, anti-inflammatory, and thrombolytic properties. Conclusion. The bioactivities of D. lindleyi, including antioxidant (root), thrombolytic (stem), and anti-inflammatory (leaf) activities, are linked to the phytochemicals detected in the screening. |
| format | Article |
| id | doaj-art-611cacd8be7c445cad6fa7976b4fa147 |
| institution | Kabale University |
| issn | 2090-908X |
| language | English |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Scientifica |
| spelling | doaj-art-611cacd8be7c445cad6fa7976b4fa1472025-02-03T06:45:21ZengWileyScientifica2090-908X2023-01-01202310.1155/2023/9999640Uncovering the Phytochemical Profile, Antioxidant Potency, Anti-Inflammatory Effects, and Thrombolytic Activity in Dendrobium lindleyi Steud.Minhajur Rahman0Roxy Begum1Abu Taleb Surag2Md. Shakhuat Hossain Tusher3Mohammed Kamrul Huda4Department of BotanyDepartment of BotanyDepartment of BotanyDepartment of PharmacyDepartment of BotanyBackground. Dendrobium genus has been used in traditional medicine to treat various illnesses. The study aims at examining the phytochemical, antioxidant, anti-inflammatory, and thrombolytic properties of the leaf, stem, and root of Dendrobium lindleyi Steud, and the relationship between phytochemicals and bioactivities is determined. Results. The qualitative screening found a variety of bioactive compounds, including alkaloids, coumarins, cardiac glycosides, glycosides, flavonoids, proteins, phenols, quinines, resins, steroids, saponins, tannins, and terpenoids, in varying amounts. The quantitative screening showed the highest concentration of alkaloids in the leaves (172.15 ± 1.22 mg/g), phenols in the root (203.55 ± 0.75 mg/g), flavonoids in the root (24.35 ± 0.42 mg/g), tannins in the leaves (105.06 ± 0.55 mg/g), and proteins in the root (194.12 ± 0.65 µg/ml). The root extract showed the highest antioxidant activity (IC50 = 58.24 µg/mL), the stem extract had the most increased thrombolytic activity (IC50 = 242.74 µg/mL), and the leaf extract had the most potent anti-inflammatory activity (IC50 = 61.79 µg/mL). Statistical analysis revealed a significant positive relationship (p=0.05) between alkaloids (r = 0.96) and tannins (r = 0.9) with antioxidant, anti-inflammatory, and thrombolytic properties. Conclusion. The bioactivities of D. lindleyi, including antioxidant (root), thrombolytic (stem), and anti-inflammatory (leaf) activities, are linked to the phytochemicals detected in the screening.http://dx.doi.org/10.1155/2023/9999640 |
| spellingShingle | Minhajur Rahman Roxy Begum Abu Taleb Surag Md. Shakhuat Hossain Tusher Mohammed Kamrul Huda Uncovering the Phytochemical Profile, Antioxidant Potency, Anti-Inflammatory Effects, and Thrombolytic Activity in Dendrobium lindleyi Steud. Scientifica |
| title | Uncovering the Phytochemical Profile, Antioxidant Potency, Anti-Inflammatory Effects, and Thrombolytic Activity in Dendrobium lindleyi Steud. |
| title_full | Uncovering the Phytochemical Profile, Antioxidant Potency, Anti-Inflammatory Effects, and Thrombolytic Activity in Dendrobium lindleyi Steud. |
| title_fullStr | Uncovering the Phytochemical Profile, Antioxidant Potency, Anti-Inflammatory Effects, and Thrombolytic Activity in Dendrobium lindleyi Steud. |
| title_full_unstemmed | Uncovering the Phytochemical Profile, Antioxidant Potency, Anti-Inflammatory Effects, and Thrombolytic Activity in Dendrobium lindleyi Steud. |
| title_short | Uncovering the Phytochemical Profile, Antioxidant Potency, Anti-Inflammatory Effects, and Thrombolytic Activity in Dendrobium lindleyi Steud. |
| title_sort | uncovering the phytochemical profile antioxidant potency anti inflammatory effects and thrombolytic activity in dendrobium lindleyi steud |
| url | http://dx.doi.org/10.1155/2023/9999640 |
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