Moderate-Intensity Exercise and Musical Co-Treatment Decreased the Circulating Level of Betatrophin
Introduction. In general, the significant contribution of lack of physical activity is strongly correlated with lipid metabolism and metabolic disorder. Hitherto, betatrophin is a potential hormone that regulates the lipid profile in the body circulation-associated triglyceride level. This study was...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2020/3098261 |
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| author | Hendra Susanto Ahmad Taufiq Sugiharto Desiana Merawati Khumaira Marsyidah Badu Jerry Dwi Trijoyo Purnomo Adeodatus Yuda Handaya |
| author_facet | Hendra Susanto Ahmad Taufiq Sugiharto Desiana Merawati Khumaira Marsyidah Badu Jerry Dwi Trijoyo Purnomo Adeodatus Yuda Handaya |
| author_sort | Hendra Susanto |
| collection | DOAJ |
| description | Introduction. In general, the significant contribution of lack of physical activity is strongly correlated with lipid metabolism and metabolic disorder. Hitherto, betatrophin is a potential hormone that regulates the lipid profile in the body circulation-associated triglyceride level. This study was designed to evaluate the alteration of betatrophin levels in subject-onset hypertriglyceridemia with exercise intervention co-treated with music. Materials and Methods. A total of 60 nonprofessional athletes were enrolled in this study and given moderate-intensity exercise (MIE) combined with middle rhythm musical co-treatment. The ELISA method was applied to quantify the serum level of betatrophin in all samples. The statistical analysis was performed by applying the Kolmogorov–Smirnov normality test, one-way ANOVA, and parametric linear correlation and regression. Results. Interestingly, our data show that MIE decreased the circulating level of betatrophin combined with music (12.47 ± 0.40 ng/mL) compared with that without musical co-treatment (20.81 ± 1.16 ng/mL) and high-intensity exercise (26.91 ± 2.23 ng/mL). The plasma level of betatrophin was positively correlated with triglycerides (r = 0.316, p≤0.05), systolic blood pressure (r = 0.428, p≤0.01), HDL (r = 0.366, p≤0.05), energy expenditure (r = 0.586, p≤0.001), PGC-1α (r = 0.573, p≤0.001), and irisin (r = 0.863, p≤0.001). By contrast, the plasma level of betatrophin was negatively associated with age (r = −0.298, p≤0.05) and LDL cholesterol (r = −0.372, p≤0.05). Importantly, betatrophin is a significant predictor for energy expenditure (p≤0.001) and plasma triglyceride levels (p≤0.05). Conclusions. Our data demonstrate that betatrophin levels decreased the post-MIE and musical therapeutical combination. Therefore, betatrophin may provide a benefit as the potential biomarker of physiological performance-associated physical training. |
| format | Article |
| id | doaj-art-61053a8f588d4519b96b94a54d5039e3 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
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| series | International Journal of Endocrinology |
| spelling | doaj-art-61053a8f588d4519b96b94a54d5039e32025-02-03T05:51:47ZengWileyInternational Journal of Endocrinology1687-83371687-83452020-01-01202010.1155/2020/30982613098261Moderate-Intensity Exercise and Musical Co-Treatment Decreased the Circulating Level of BetatrophinHendra Susanto0Ahmad Taufiq1Sugiharto2Desiana Merawati3Khumaira Marsyidah Badu4Jerry Dwi Trijoyo Purnomo5Adeodatus Yuda Handaya6Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Malang, IndonesiaDepartment of Physics, Faculty of Mathematics and Natural Sciences, Universitas Negeri Malang, Malang, IndonesiaDepartment of Sports Science, Faculty of Sports Science, Universitas Negeri Malang, Malang, IndonesiaDepartment of Sports Science, Faculty of Sports Science, Universitas Negeri Malang, Malang, IndonesiaDepartment of Sports Science, Faculty of Sports Science, Universitas Negeri Malang, Malang, IndonesiaDepartment of Statistics, Faculty of Science and Data Analytics, Institut Teknologi Sepuluh Nopember, Surabaya, IndonesiaFaculty of Medicine, Universitas Gadjah Mada, Yogyakarta, IndonesiaIntroduction. In general, the significant contribution of lack of physical activity is strongly correlated with lipid metabolism and metabolic disorder. Hitherto, betatrophin is a potential hormone that regulates the lipid profile in the body circulation-associated triglyceride level. This study was designed to evaluate the alteration of betatrophin levels in subject-onset hypertriglyceridemia with exercise intervention co-treated with music. Materials and Methods. A total of 60 nonprofessional athletes were enrolled in this study and given moderate-intensity exercise (MIE) combined with middle rhythm musical co-treatment. The ELISA method was applied to quantify the serum level of betatrophin in all samples. The statistical analysis was performed by applying the Kolmogorov–Smirnov normality test, one-way ANOVA, and parametric linear correlation and regression. Results. Interestingly, our data show that MIE decreased the circulating level of betatrophin combined with music (12.47 ± 0.40 ng/mL) compared with that without musical co-treatment (20.81 ± 1.16 ng/mL) and high-intensity exercise (26.91 ± 2.23 ng/mL). The plasma level of betatrophin was positively correlated with triglycerides (r = 0.316, p≤0.05), systolic blood pressure (r = 0.428, p≤0.01), HDL (r = 0.366, p≤0.05), energy expenditure (r = 0.586, p≤0.001), PGC-1α (r = 0.573, p≤0.001), and irisin (r = 0.863, p≤0.001). By contrast, the plasma level of betatrophin was negatively associated with age (r = −0.298, p≤0.05) and LDL cholesterol (r = −0.372, p≤0.05). Importantly, betatrophin is a significant predictor for energy expenditure (p≤0.001) and plasma triglyceride levels (p≤0.05). Conclusions. Our data demonstrate that betatrophin levels decreased the post-MIE and musical therapeutical combination. Therefore, betatrophin may provide a benefit as the potential biomarker of physiological performance-associated physical training.http://dx.doi.org/10.1155/2020/3098261 |
| spellingShingle | Hendra Susanto Ahmad Taufiq Sugiharto Desiana Merawati Khumaira Marsyidah Badu Jerry Dwi Trijoyo Purnomo Adeodatus Yuda Handaya Moderate-Intensity Exercise and Musical Co-Treatment Decreased the Circulating Level of Betatrophin International Journal of Endocrinology |
| title | Moderate-Intensity Exercise and Musical Co-Treatment Decreased the Circulating Level of Betatrophin |
| title_full | Moderate-Intensity Exercise and Musical Co-Treatment Decreased the Circulating Level of Betatrophin |
| title_fullStr | Moderate-Intensity Exercise and Musical Co-Treatment Decreased the Circulating Level of Betatrophin |
| title_full_unstemmed | Moderate-Intensity Exercise and Musical Co-Treatment Decreased the Circulating Level of Betatrophin |
| title_short | Moderate-Intensity Exercise and Musical Co-Treatment Decreased the Circulating Level of Betatrophin |
| title_sort | moderate intensity exercise and musical co treatment decreased the circulating level of betatrophin |
| url | http://dx.doi.org/10.1155/2020/3098261 |
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