Ex Vivo Test of Complement Dysregulation in Atypical Hemolytic Uremic Syndrome Kidney Transplant patients: A Pilot Study

Ex Vivo Test of Complement Dysregulation in Atypical Hemolytic Uremic Syndrome Kidney Transplant patients: A Pilot Study

Introduction: In 2014, a complement assay, which evaluates C5b-9 deposition on endothelial cells, was proposed as a biomarker for atypical hemolytic uremic syndrome (aHUS). Early diagnosis and/or prediction of aHUS (relapse) is pivotal in aHUS kidney transplant recipients who do not receive eculizum...

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Bibliographic Details
Main Authors: Caroline Duineveld, Romy N. Bouwmeester, Lambertus P.W.J. van den Heuvel, Nicole C.A.J. van de Kar, Jack F.M. Wetzels
Format: Article
Language:English
Published: Elsevier 2024-01-01
Series:Kidney International Reports
Subjects:
atypical hemolytic uremic syndrome
biomarker
C5b-9 deposition
ex vivo complement assay
kidney transplantation
thrombotic microangiopathy
Online Access:http://www.sciencedirect.com/science/article/pii/S2468024923015322
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http://www.sciencedirect.com/science/article/pii/S2468024923015322

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