CXCL-10 in Cerebrospinal Fluid Detects Neuroinflammation in HTLV-1-Associated Myelopathy with High Accuracy
Background and Objectives: HTLV-1-associated myelopathy (HAM) is a chronic progressive inflammatory disease of the spinal cord. This study assesses the diagnostic accuracy of the neuroinflammatory biomarkers neopterin and cysteine-X-cysteine motif chemokine ligand 10 (CXCL-10) in cerebrospinal fluid...
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2025-01-01
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| Online Access: | https://www.mdpi.com/1999-4915/17/1/89 |
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| author | Samya Jezine Da Silva Mauro Jorge Cabral-Castro Luiz Claudio Faria Carolina Rosadas Maria Fernanda Lopes de Araújo Ana Caroline Soares Dutra Yoshihisa Yamano Graham Taylor Marzia Puccioni-Sohler |
| author_facet | Samya Jezine Da Silva Mauro Jorge Cabral-Castro Luiz Claudio Faria Carolina Rosadas Maria Fernanda Lopes de Araújo Ana Caroline Soares Dutra Yoshihisa Yamano Graham Taylor Marzia Puccioni-Sohler |
| author_sort | Samya Jezine Da Silva |
| collection | DOAJ |
| description | Background and Objectives: HTLV-1-associated myelopathy (HAM) is a chronic progressive inflammatory disease of the spinal cord. This study assesses the diagnostic accuracy of the neuroinflammatory biomarkers neopterin and cysteine-X-cysteine motif chemokine ligand 10 (CXCL-10) in cerebrospinal fluid (CSF) for HAM. Methods: CSF samples from 75 patients with neurological disorders—33 with HAM (Group A), 19 HTLV-1-seronegative with other neuroinflammatory diseases (Group B), and 23 HTLV-1-seronegative with non-neuroinflammatory diseases (Group C)—were retrospectively evaluated. CSF examination included routine analysis, neopterin, and CXCL-10. The diagnostic potential of the biomarkers was evaluated using receiver operating characteristic curves. Results: Higher white cell counts and concentrations of protein, neopterin, and CXCL-10 in CSF were detected in group A (patients with HAM) and group B (<i>p</i> < 0.05). Neopterin showed good accuracy for HAM (A) (cut-off 15 nmol/L, 80% sensitivity, 74% specificity) and other neuroinflammation (group B) (cut-off 20 nmol/L, 79% sensitivity, 83% specificity). CXCL-10 demonstrated the highest accuracy in both groups, with Group A (cut-off 110 pg/mL, 97% sensitivity, 96% specificity) and Group B (cut-off 220 pg/mL, 100% sensitivity, 100% specificity). Conclusions: Neopterin and CXCL-10 in CSF are accurate biomarkers for detecting neuroinflammation, including HAM. CXCL-10, in particular, is the superior biomarker for both chronic and acute neuroinflammatory diseases. |
| format | Article |
| id | doaj-art-60eaa01f09bc4e038411e5a74de04572 |
| institution | Kabale University |
| issn | 1999-4915 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj-art-60eaa01f09bc4e038411e5a74de045722025-01-24T13:52:33ZengMDPI AGViruses1999-49152025-01-011718910.3390/v17010089CXCL-10 in Cerebrospinal Fluid Detects Neuroinflammation in HTLV-1-Associated Myelopathy with High AccuracySamya Jezine Da Silva0Mauro Jorge Cabral-Castro1Luiz Claudio Faria2Carolina Rosadas3Maria Fernanda Lopes de Araújo4Ana Caroline Soares Dutra5Yoshihisa Yamano6Graham Taylor7Marzia Puccioni-Sohler8Programa de Pós-Graduação em Doenças Infecciosas e Parasitárias, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-913, BrazilDepartamento de Patologia—Programa de Pós-Graduação em Patologia, Faculdade de Medicina, Universidade Federal Fluminense, Niterói 24070-090, BrazilLaboratório de Líquido Cefalorraquidiano, Hospital Universitário Clementino Fraga Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-913, BrazilSection of Virology, Department of Infectious Disease, Imperial College, London W2 1PG, UKEscola de Medicina e Cirurgia, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro 20270-004, BrazilEscola de Medicina e Cirurgia, Universidade Federal do Estado do Rio de Janeiro, Rio de Janeiro 20270-004, BrazilDepartment of Neurology, St. Marianna University School of Medicine, Kawasaki 216-8512, JapanSection of Virology, Department of Infectious Disease, Imperial College, London W2 1PG, UKPrograma de Pós-Graduação em Doenças Infecciosas e Parasitárias, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro 21941-913, BrazilBackground and Objectives: HTLV-1-associated myelopathy (HAM) is a chronic progressive inflammatory disease of the spinal cord. This study assesses the diagnostic accuracy of the neuroinflammatory biomarkers neopterin and cysteine-X-cysteine motif chemokine ligand 10 (CXCL-10) in cerebrospinal fluid (CSF) for HAM. Methods: CSF samples from 75 patients with neurological disorders—33 with HAM (Group A), 19 HTLV-1-seronegative with other neuroinflammatory diseases (Group B), and 23 HTLV-1-seronegative with non-neuroinflammatory diseases (Group C)—were retrospectively evaluated. CSF examination included routine analysis, neopterin, and CXCL-10. The diagnostic potential of the biomarkers was evaluated using receiver operating characteristic curves. Results: Higher white cell counts and concentrations of protein, neopterin, and CXCL-10 in CSF were detected in group A (patients with HAM) and group B (<i>p</i> < 0.05). Neopterin showed good accuracy for HAM (A) (cut-off 15 nmol/L, 80% sensitivity, 74% specificity) and other neuroinflammation (group B) (cut-off 20 nmol/L, 79% sensitivity, 83% specificity). CXCL-10 demonstrated the highest accuracy in both groups, with Group A (cut-off 110 pg/mL, 97% sensitivity, 96% specificity) and Group B (cut-off 220 pg/mL, 100% sensitivity, 100% specificity). Conclusions: Neopterin and CXCL-10 in CSF are accurate biomarkers for detecting neuroinflammation, including HAM. CXCL-10, in particular, is the superior biomarker for both chronic and acute neuroinflammatory diseases.https://www.mdpi.com/1999-4915/17/1/89accuracydiagnosisHTLV-1-associated myelopathycerebrospinal fluidneopterinCXCL-10 |
| spellingShingle | Samya Jezine Da Silva Mauro Jorge Cabral-Castro Luiz Claudio Faria Carolina Rosadas Maria Fernanda Lopes de Araújo Ana Caroline Soares Dutra Yoshihisa Yamano Graham Taylor Marzia Puccioni-Sohler CXCL-10 in Cerebrospinal Fluid Detects Neuroinflammation in HTLV-1-Associated Myelopathy with High Accuracy Viruses accuracy diagnosis HTLV-1-associated myelopathy cerebrospinal fluid neopterin CXCL-10 |
| title | CXCL-10 in Cerebrospinal Fluid Detects Neuroinflammation in HTLV-1-Associated Myelopathy with High Accuracy |
| title_full | CXCL-10 in Cerebrospinal Fluid Detects Neuroinflammation in HTLV-1-Associated Myelopathy with High Accuracy |
| title_fullStr | CXCL-10 in Cerebrospinal Fluid Detects Neuroinflammation in HTLV-1-Associated Myelopathy with High Accuracy |
| title_full_unstemmed | CXCL-10 in Cerebrospinal Fluid Detects Neuroinflammation in HTLV-1-Associated Myelopathy with High Accuracy |
| title_short | CXCL-10 in Cerebrospinal Fluid Detects Neuroinflammation in HTLV-1-Associated Myelopathy with High Accuracy |
| title_sort | cxcl 10 in cerebrospinal fluid detects neuroinflammation in htlv 1 associated myelopathy with high accuracy |
| topic | accuracy diagnosis HTLV-1-associated myelopathy cerebrospinal fluid neopterin CXCL-10 |
| url | https://www.mdpi.com/1999-4915/17/1/89 |
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