Association of Dipeptidiyl Peptidase-4 Inhibitors and Bullose Pemphigoid: A Report of Four Cases
Dipeptidyl-peptidase 4 inhibitors (DPP4i) are commonly used as antidiabetic medications. Although these drugs are generally recognized for their favorable clinical safety profile, emerging evidence points to the potential for adverse events associated with DPP4i. Notably, cases of bullous pemphigoid...
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| Format: | Article |
| Language: | English |
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Galenos Publishing House
2024-06-01
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| Series: | Medeniyet Medical Journal |
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| Online Access: | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-76508 |
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| author | Neslihan USLU Kagan GUNGOR Gonca TAMER Bulent CAN |
| author_facet | Neslihan USLU Kagan GUNGOR Gonca TAMER Bulent CAN |
| author_sort | Neslihan USLU |
| collection | DOAJ |
| description | Dipeptidyl-peptidase 4 inhibitors (DPP4i) are commonly used as antidiabetic medications. Although these drugs are generally recognized for their favorable clinical safety profile, emerging evidence points to the potential for adverse events associated with DPP4i. Notably, cases of bullous pemphigoid (BP) linked to DPP4i therapy have recently been documented in the medical literature. This report presents four cases of BP in elderly patients resulting from DPP4i treatment, involving two cases with ligandliptin and two with vildagliptin use. Successful remission was achieved in all cases through discontinuation of the implicated medication and implementation of topical corticosteroid therapy. It is imperative for clinicians to be vigilant about the potential risk of BP development when employing DPP4i drugs, particularly in the context of elderly patients with diabetes. |
| format | Article |
| id | doaj-art-60d30a910d9549a3b8742b7ba6642932 |
| institution | Kabale University |
| issn | 2149-2042 2149-4606 |
| language | English |
| publishDate | 2024-06-01 |
| publisher | Galenos Publishing House |
| record_format | Article |
| series | Medeniyet Medical Journal |
| spelling | doaj-art-60d30a910d9549a3b8742b7ba66429322025-01-29T10:24:23ZengGalenos Publishing HouseMedeniyet Medical Journal2149-20422149-46062024-06-0139214014310.4274/MMJ.galenos.2024.76508MEDJ-76508Association of Dipeptidiyl Peptidase-4 Inhibitors and Bullose Pemphigoid: A Report of Four CasesNeslihan USLU0Kagan GUNGOR1Gonca TAMER2Bulent CAN3Istanbul Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Clinic of Internal Medicine, Division of Endocrinology and Metabolic Diseases, Istanbul, TürkiyeIstanbul Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Clinic of Internal Medicine, Division of Endocrinology and Metabolic Diseases, Istanbul, TürkiyeIstanbul Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Clinic of Internal Medicine, Division of Endocrinology and Metabolic Diseases, Istanbul, TürkiyeIstanbul Goztepe Prof. Dr. Suleyman Yalcin City Hospital, Clinic of Internal Medicine, Division of Endocrinology and Metabolic Diseases, Istanbul, TürkiyeDipeptidyl-peptidase 4 inhibitors (DPP4i) are commonly used as antidiabetic medications. Although these drugs are generally recognized for their favorable clinical safety profile, emerging evidence points to the potential for adverse events associated with DPP4i. Notably, cases of bullous pemphigoid (BP) linked to DPP4i therapy have recently been documented in the medical literature. This report presents four cases of BP in elderly patients resulting from DPP4i treatment, involving two cases with ligandliptin and two with vildagliptin use. Successful remission was achieved in all cases through discontinuation of the implicated medication and implementation of topical corticosteroid therapy. It is imperative for clinicians to be vigilant about the potential risk of BP development when employing DPP4i drugs, particularly in the context of elderly patients with diabetes.https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-76508bullose pemphigoiddpp4idipeptidyl peptidase 4 inhibitors |
| spellingShingle | Neslihan USLU Kagan GUNGOR Gonca TAMER Bulent CAN Association of Dipeptidiyl Peptidase-4 Inhibitors and Bullose Pemphigoid: A Report of Four Cases Medeniyet Medical Journal bullose pemphigoid dpp4i dipeptidyl peptidase 4 inhibitors |
| title | Association of Dipeptidiyl Peptidase-4 Inhibitors and Bullose Pemphigoid: A Report of Four Cases |
| title_full | Association of Dipeptidiyl Peptidase-4 Inhibitors and Bullose Pemphigoid: A Report of Four Cases |
| title_fullStr | Association of Dipeptidiyl Peptidase-4 Inhibitors and Bullose Pemphigoid: A Report of Four Cases |
| title_full_unstemmed | Association of Dipeptidiyl Peptidase-4 Inhibitors and Bullose Pemphigoid: A Report of Four Cases |
| title_short | Association of Dipeptidiyl Peptidase-4 Inhibitors and Bullose Pemphigoid: A Report of Four Cases |
| title_sort | association of dipeptidiyl peptidase 4 inhibitors and bullose pemphigoid a report of four cases |
| topic | bullose pemphigoid dpp4i dipeptidyl peptidase 4 inhibitors |
| url | https://jag.journalagent.com/z4/download_fulltext.asp?pdir=medeniyet&un=MEDJ-76508 |
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