Amyloid-β-induced alteration of fast and localized calcium elevations in cultured astrocytes

Amyloid-β-induced alteration of fast and localized calcium elevations in cultured astrocytes

Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disorder that causes cognitive decline. Uncovering the mechanisms of neurodegeneration in the early stages is essential to establish a treatment for AD. Recent research has proposed the hypothesis that amyloid-β (Aβ) oligomers elic...

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Bibliographic Details
Main Authors: Kaito Nakata, Joe Sakamoto, Kohei Otomo, Masanao Sato, Hirokazu Ishii, Motosuke Tsutsumi, Ryosuke Enoki, Tomomi Nemoto
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Amyloid-β
Alzheimer’s disease
Astrocyte
Ca2+
Two-photon microscopy
Online Access:https://doi.org/10.1038/s41598-025-03931-7
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