VHL Genetic Alteration in CCRCC Does Not Determine De-Regulation of HIF, CAIX, hnRNP A2/B1 and Osteopontin

VHL Genetic Alteration in CCRCC Does Not Determine De-Regulation of HIF, CAIX, hnRNP A2/B1 and Osteopontin

Background: von Hippel–Lindau (VHL) tumour suppressor gene inactivation is associated with clear cell renal cell carcinoma (CCRCC) development. The VHL protein (pVHL) has been proposed to regulate the expression of several proteins including Hypoxia Inducible Factor-α (HIF-α), carbonic anhydrase (CA...

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Main Authors: Michelle J. Nyhan, Shereen M. El Mashad, Tracey R. O’Donovan, Sarfraz Ahmad, Chris Collins, Paul Sweeney, Eamonn Rogers, Gerald C. O’Sullivan, Sharon L. McKenna
Format: Article
Language:English
Published: Wiley 2010-01-01
Series:Analytical Cellular Pathology
Online Access:http://dx.doi.org/10.3233/ACP-CLO-2010-0541
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http://dx.doi.org/10.3233/ACP-CLO-2010-0541

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