Sinigrin Encapsulation in Liposomes: Influence on In Vitro Digestion and Antioxidant Potential
Encapsulation of sinigrin in liposomes with the proliposomal method was performed in order to evaluate the effect of this process on in vitro simulated digestion and antioxidant potential of sinigrin. The recovery of sinigrin after simulated gastric and duodenal digestion of its free and liposomal...
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Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences
2021-11-01
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| Series: | Polish Journal of Food and Nutrition Sciences |
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| Online Access: | http://journal.pan.olsztyn.pl/Sinigrin-Encapsulation-in-Liposomes-Influence-on-In-Vitro-Digestion-and-Antioxidant,143574,0,2.html |
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| author | Ivana Drvenica Ivica Blažević Perica Bošković Andre Bratanić Branko Bugarski Tea Bilusic |
| author_facet | Ivana Drvenica Ivica Blažević Perica Bošković Andre Bratanić Branko Bugarski Tea Bilusic |
| author_sort | Ivana Drvenica |
| collection | DOAJ |
| description | Encapsulation of sinigrin in liposomes with the proliposomal method was performed in order to evaluate the effect of this process on in vitro simulated digestion and antioxidant potential of sinigrin. The recovery of sinigrin after simulated gastric and duodenal digestion of its free and liposomal forms was determined with HPLC-UV using human digestive juices. The antioxidant potential of sinigrin and sinigrin-loaded liposomes was determined with the Rancimat test as their ability to prolong oxidative stability of edible oil. The efficiency of 62% was obtained by encapsulating sinigrin in liposomes. The values of mean diameter, polydispersity index and zeta potential showed satisfactory size uniformity and physical stability of the liposomes containing sinigrin. Liposomes were shown to inhibit the digestion of sinigrin in both human gastric and intestinal juices, clearly enabling its prolonged release. Moreover, sinigrin in the liposomal form significantly prolonged the induction time of edible oil oxidation compared to its free form. The results obtained are encouraging from the point of view of a possible incorporation of the sinigrin-loaded liposomes in real functional food systems or their use as nutraceuticals. |
| format | Article |
| id | doaj-art-607a2bd5a71b4d059702997f4e9285bf |
| institution | Kabale University |
| issn | 2083-6007 |
| language | English |
| publishDate | 2021-11-01 |
| publisher | Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences |
| record_format | Article |
| series | Polish Journal of Food and Nutrition Sciences |
| spelling | doaj-art-607a2bd5a71b4d059702997f4e9285bf2025-02-02T12:29:41ZengInstitute of Animal Reproduction and Food Research of the Polish Academy of SciencesPolish Journal of Food and Nutrition Sciences2083-60072021-11-0171444144910.31883/pjfns/143574143574Sinigrin Encapsulation in Liposomes: Influence on In Vitro Digestion and Antioxidant PotentialIvana Drvenica0https://orcid.org/0000-0003-4985-1642Ivica Blažević1https://orcid.org/0000-0002-0715-3216Perica Bošković2Andre Bratanić3https://orcid.org/0000-0002-3261-183XBranko Bugarski4https://orcid.org/0000-0002-1846-8555Tea Bilusic5https://orcid.org/0000-0001-8834-9562Institute for Medical Research, University of Belgrade, Dr Subotića 4, 11000 Belgrade, SerbiaFaculty of Chemistry and Technology, University of Split, Ruđera Boškovića 35, 21000 Split, CroatiaFaculty of Science, University of Split, Ruđera Boškovića 33, 21000 Split, CroatiaDivision of Gastroenterology and Hepatology, University Hospital Split, Spinčićeva 1, 21000 Split, CroatiaFaculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, 11000 Belgrade, SerbiaInstitute for Medical Research, University of Belgrade, Dr Subotića 4, 11000 Belgrade, SerbiaEncapsulation of sinigrin in liposomes with the proliposomal method was performed in order to evaluate the effect of this process on in vitro simulated digestion and antioxidant potential of sinigrin. The recovery of sinigrin after simulated gastric and duodenal digestion of its free and liposomal forms was determined with HPLC-UV using human digestive juices. The antioxidant potential of sinigrin and sinigrin-loaded liposomes was determined with the Rancimat test as their ability to prolong oxidative stability of edible oil. The efficiency of 62% was obtained by encapsulating sinigrin in liposomes. The values of mean diameter, polydispersity index and zeta potential showed satisfactory size uniformity and physical stability of the liposomes containing sinigrin. Liposomes were shown to inhibit the digestion of sinigrin in both human gastric and intestinal juices, clearly enabling its prolonged release. Moreover, sinigrin in the liposomal form significantly prolonged the induction time of edible oil oxidation compared to its free form. The results obtained are encouraging from the point of view of a possible incorporation of the sinigrin-loaded liposomes in real functional food systems or their use as nutraceuticals.http://journal.pan.olsztyn.pl/Sinigrin-Encapsulation-in-Liposomes-Influence-on-In-Vitro-Digestion-and-Antioxidant,143574,0,2.htmlsinigrinliposomesoxidative stabilitygastric digestionduodenal digestionantioxidant potential |
| spellingShingle | Ivana Drvenica Ivica Blažević Perica Bošković Andre Bratanić Branko Bugarski Tea Bilusic Sinigrin Encapsulation in Liposomes: Influence on In Vitro Digestion and Antioxidant Potential Polish Journal of Food and Nutrition Sciences sinigrin liposomes oxidative stability gastric digestion duodenal digestion antioxidant potential |
| title | Sinigrin Encapsulation in Liposomes: Influence on In Vitro Digestion and Antioxidant Potential |
| title_full | Sinigrin Encapsulation in Liposomes: Influence on In Vitro Digestion and Antioxidant Potential |
| title_fullStr | Sinigrin Encapsulation in Liposomes: Influence on In Vitro Digestion and Antioxidant Potential |
| title_full_unstemmed | Sinigrin Encapsulation in Liposomes: Influence on In Vitro Digestion and Antioxidant Potential |
| title_short | Sinigrin Encapsulation in Liposomes: Influence on In Vitro Digestion and Antioxidant Potential |
| title_sort | sinigrin encapsulation in liposomes influence on in vitro digestion and antioxidant potential |
| topic | sinigrin liposomes oxidative stability gastric digestion duodenal digestion antioxidant potential |
| url | http://journal.pan.olsztyn.pl/Sinigrin-Encapsulation-in-Liposomes-Influence-on-In-Vitro-Digestion-and-Antioxidant,143574,0,2.html |
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