Impact of germline variants on breast and ovarian cancer risk in Japanese women: an original cohort study and meta-analysisResearch in context

Impact of germline variants on breast and ovarian cancer risk in Japanese women: an original cohort study and meta-analysisResearch in context

Summary: Background: Pathogenic variants (PVs) of BRCA1 and BRCA2 predispose individuals to a higher risk of breast and ovarian cancer; however, the precise risks posed by other cancer susceptibility genes remain unclear, particularly in Asian populations. Methods: We executed a case–control study...

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Main Authors: Shu Yazaki, Megumi Hori, Hisaki Aiba, Yukihide Momozawa, Masayuki Yoshida, Sho Shiino, Kenichi Harano, Chisako Yamauchi, Takashi Yamanaka, Maiko Miwa, Koichi Matsuda, Yosuke Kawai, Mayumi Kobayashi-Kato, Masakazu Kitagawa, Motonobu Saito, Hiroshi Nakagomi, Kazunoshin Tachibana, Ikuko Sakamoto, Kazuaki Takahashi, Yuka Asami, Kota Katanoda, Aya Kuchiba, Hiroshi Yoshida, Mitsuya Ishikawa, Tastunori Shimoi, Kazuki Sudo, Chikako Shimizu, Akihiko Shimomura, Takeshi Murata, Yuji Yamashita, Takahiro Kogawa, Saori Fujiwara, Haruya Saji, Hisamori Kato, Etsuko Miyagi, Yusuke Iwasaki, Tomomi Aoi, Sadaaki Takata, Aiko Ogasawara, Tohru Ohtake, Keiya Fujimori, Yosuke Hirotsu, Minoru Nagashima, Masaaki Komatsu, Ryuji Hamamoto, Makoto Hirata, Teruhiko Yoshida, Takayuki Honda, Kengo Hiranuma, Maiko Matsuda, Yoko Shimada, Kuniko Sunami, Eisei Noiri, Yosuke Omae, Koji Matsumoto, Aikou Okamoto, Masao Omata, Takafumi Watanabe, Yohei Miyagi, Yoshinori Murakami, Katsushi Tokunaga, Kosei Hasegawa, Tomoyasu Kato, Tatsuya Onishi, Toshinari Yamashita, Yoichi Naito, Akihiko Suto, Kan Yonemori, Takashi Kohno, Kouya Shiraisihi
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:EBioMedicine
Subjects:
Breast cancer
Ovarian cancer
Cancer predisposition genes
Cumulative cancer risk
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396425002026
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