Sex Differences in Spontaneous Degranulation Activity of Intrahepatic Natural Killer Cells during Chronic Hepatitis B: Association with Estradiol Levels
Major sex differences are observed in the prevalence, intensity, and severity of hepatitis B virus (HBV) infection. Here, we investigated degranulation activity of circulating and intrahepatic natural killer (NK) cells from HBV and HCV chronically infected patients before any treatment (n=125). The...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2017/3214917 |
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| author | Zuzana Macek Jilkova Thomas Decaens Alice Marlu Hélène Marche Evelyne Jouvin-Marche Patrice N. Marche |
| author_facet | Zuzana Macek Jilkova Thomas Decaens Alice Marlu Hélène Marche Evelyne Jouvin-Marche Patrice N. Marche |
| author_sort | Zuzana Macek Jilkova |
| collection | DOAJ |
| description | Major sex differences are observed in the prevalence, intensity, and severity of hepatitis B virus (HBV) infection. Here, we investigated degranulation activity of circulating and intrahepatic natural killer (NK) cells from HBV and HCV chronically infected patients before any treatment (n=125). The frequency of CD107+ NK cells in the female liver was significantly higher compared to that in males during chronic HBV infection (p=0.002) and correlated with the plasma levels of estradiol (correlation coefficient r=0.634; p<0.0001). Our results clearly show sex differences in degranulation activity of intrahepatic NK cells of HBV-infected patients. This probably contributes to the ability of females to better deal with HBV disease. |
| format | Article |
| id | doaj-art-5fe4203d67f24757aed1150bdf6bcc57 |
| institution | Kabale University |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-5fe4203d67f24757aed1150bdf6bcc572025-02-03T01:30:57ZengWileyMediators of Inflammation0962-93511466-18612017-01-01201710.1155/2017/32149173214917Sex Differences in Spontaneous Degranulation Activity of Intrahepatic Natural Killer Cells during Chronic Hepatitis B: Association with Estradiol LevelsZuzana Macek Jilkova0Thomas Decaens1Alice Marlu2Hélène Marche3Evelyne Jouvin-Marche4Patrice N. Marche5Université Grenoble-Alpes, IAB, 38000 Grenoble, FranceUniversité Grenoble-Alpes, IAB, 38000 Grenoble, FranceDépartement d’Hépato-Gastro-Entérologie, CHU-Grenoble Alpes, 30700 La Tronche, FranceUniversité Grenoble-Alpes, IAB, 38000 Grenoble, FranceUniversité Grenoble-Alpes, IAB, 38000 Grenoble, FranceUniversité Grenoble-Alpes, IAB, 38000 Grenoble, FranceMajor sex differences are observed in the prevalence, intensity, and severity of hepatitis B virus (HBV) infection. Here, we investigated degranulation activity of circulating and intrahepatic natural killer (NK) cells from HBV and HCV chronically infected patients before any treatment (n=125). The frequency of CD107+ NK cells in the female liver was significantly higher compared to that in males during chronic HBV infection (p=0.002) and correlated with the plasma levels of estradiol (correlation coefficient r=0.634; p<0.0001). Our results clearly show sex differences in degranulation activity of intrahepatic NK cells of HBV-infected patients. This probably contributes to the ability of females to better deal with HBV disease.http://dx.doi.org/10.1155/2017/3214917 |
| spellingShingle | Zuzana Macek Jilkova Thomas Decaens Alice Marlu Hélène Marche Evelyne Jouvin-Marche Patrice N. Marche Sex Differences in Spontaneous Degranulation Activity of Intrahepatic Natural Killer Cells during Chronic Hepatitis B: Association with Estradiol Levels Mediators of Inflammation |
| title | Sex Differences in Spontaneous Degranulation Activity of Intrahepatic Natural Killer Cells during Chronic Hepatitis B: Association with Estradiol Levels |
| title_full | Sex Differences in Spontaneous Degranulation Activity of Intrahepatic Natural Killer Cells during Chronic Hepatitis B: Association with Estradiol Levels |
| title_fullStr | Sex Differences in Spontaneous Degranulation Activity of Intrahepatic Natural Killer Cells during Chronic Hepatitis B: Association with Estradiol Levels |
| title_full_unstemmed | Sex Differences in Spontaneous Degranulation Activity of Intrahepatic Natural Killer Cells during Chronic Hepatitis B: Association with Estradiol Levels |
| title_short | Sex Differences in Spontaneous Degranulation Activity of Intrahepatic Natural Killer Cells during Chronic Hepatitis B: Association with Estradiol Levels |
| title_sort | sex differences in spontaneous degranulation activity of intrahepatic natural killer cells during chronic hepatitis b association with estradiol levels |
| url | http://dx.doi.org/10.1155/2017/3214917 |
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