Angiotensin Ⅱ type 1 receptor autoantibody-AT1R-Bmal1 axis promotes phenotypic transition of vascular smooth muscle cells and vascular fibrosis

Angiotensin Ⅱ type 1 receptor autoantibody-AT1R-Bmal1 axis promotes phenotypic transition of vascular smooth muscle cells and vascular fibrosis

‍Objective‍　‍To investigate the mechanism by which angiotensin Ⅱ type 1 receptor autoantibody (AT1-AA) promotes phenotypic switch of vascular smooth muscle cells (VSMCs) and vascular fibrosis through abnormal expression of circadian clock protein BMAL1. Methods‍　‍Twelve male SD rats (6~8 weeks old,...

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Bibliographic Details
Main Authors: XUE Lingxia, LONG Yaolin, FENG Jiayan
Format: Article
Language:zho
Published: Editorial Office of Journal of Army Medical University 2025-06-01
Series:陆军军医大学学报
Subjects:
‍angiotensin ⅱ-1 type 1 receptor autoantibody
bmal1
angiotensin ⅱ-1 type 1 receptor
vascular smooth muscle cells
phenotypic transition
vascular fibrosis
Online Access:https://aammt.tmmu.edu.cn/html/202412142.html
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