Baicalin reduces sunitinib-induced cardiotoxicity in renal carcinoma PDX model by inhibiting myocardial injury, apoptosis and fibrosis

Baicalin reduces sunitinib-induced cardiotoxicity in renal carcinoma PDX model by inhibiting myocardial injury, apoptosis and fibrosis

Sunitinib (SU), a multi-targeted tyrosine kinase inhibitor, has anticancer function but its clinical use is often limited by cardiovascular complications. Baicalin (BA) has demonstrated various pharmacological activities including antioxidant, anti-inflammatory and antiviral properties, but its pote...

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Bibliographic Details
Main Authors: Zefu Yang, Jianping Wan, Xinjin Zhang, Jiaqi Mei, Hua Hao, Sibo Liu, Yun Yi, Meixiu Jiang, Yuanqiao He
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Pharmacology
Subjects:
baicalin
sunitinib
cardiotoxicity
renal carcinoma
PDX
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1563194/full
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