GENI as an AMPK Activator Binds α and γ Subunits and Improves the Memory Dysfunction of Alzheimer’s Disease Mouse Models via Autophagy and Neuroprotection

GENI as an AMPK Activator Binds α and γ Subunits and Improves the Memory Dysfunction of Alzheimer’s Disease Mouse Models via Autophagy and Neuroprotection

Geniposidic 4-isoamyl ester (GENI) with anti-aging effects is a new iridoid glycoside derivative from <i>Gardenia jasminoides</i> Ellis found in our previous study. In this study, to indicate whether this compound has anti-Alzheimer’s disease (AD) effect, the galactose-induced AD mice an...

Full description

Saved in:
Bibliographic Details
Main Authors: Ying Wang, Lanjie Li, Danni Chen, Jiaheng Shan, Meijuan Yi, Hiroyuki Osada, Minoru Yoshida, Lan Xiang, Jianhua Qi
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Antioxidants
Subjects:
iridoid glycoside
AMP-activated protein kinase
autophagy
neuroprotection
Alzheimer’s disease
target identification
Online Access:https://www.mdpi.com/2076-3921/14/1/57
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items

Similar Items