Factors Affecting Negative Symptoms in Schizophrenia and Their Relationship with Anxiety and Depression
Gang Zeng,1,2,* Rongyu Liang,2,3,* Lingxian Xiao,2,4,* Weiye Cao,5 Wenqing Zhou,2,6 Wen Wang,5 Cuixia Liu,2,7 Huarong Zhou,1,2 Xiaolei Shi,1,2 Ben Chen,1,2 Wanhua Chen2,4 1Geriatric Neuroscience Center, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, P...
Saved in:
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2025-02-01
|
| Series: | Neuropsychiatric Disease and Treatment |
| Subjects: | |
| Online Access: | https://www.dovepress.com/factors-affecting-negative-symptoms-in-schizophrenia-and-their-relatio-peer-reviewed-fulltext-article-NDT |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832540599552573440 |
|---|---|
| author | Zeng G Liang R Xiao L Cao W Zhou W Wang W Liu C Zhou H Shi X Chen B Chen W |
| author_facet | Zeng G Liang R Xiao L Cao W Zhou W Wang W Liu C Zhou H Shi X Chen B Chen W |
| author_sort | Zeng G |
| collection | DOAJ |
| description | Gang Zeng,1,2,* Rongyu Liang,2,3,* Lingxian Xiao,2,4,* Weiye Cao,5 Wenqing Zhou,2,6 Wen Wang,5 Cuixia Liu,2,7 Huarong Zhou,1,2 Xiaolei Shi,1,2 Ben Chen,1,2 Wanhua Chen2,4 1Geriatric Neuroscience Center, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of China; 2Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, People’s Republic of China; 3Department of Geriatric Psychiatry, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of China; 4Department of Nursing, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of China; 5School of Nursing, Guangzhou Medical University, Guangzhou, People’s Republic of China; 6Adult Psychiatry Department, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of China; 7Chronic Psychiatry Department, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wenqing Zhou, Adult Psychiatry Department, Affiliated Brain Hospital of Guangzhou Medical University, 36 mingXin Road, Liwan District, Guangzhou, People’s Republic of China, Tel +86 15918636953, Email 996459134@qq.com Weiye Cao, School of Nursing, Guangzhou Medical University, 195 Dongfeng West Road, Yuexiu District, Guangzhou, People’s Republic of China, Tel +86 13149399874, Email 1271932456@qq.comObjective: Negative symptoms significantly impair daily functioning and worsen clinical outcomes. Meanwhile, these symptoms are closely linked to anxiety and depression, further complicating prognosis. The mechanisms underlying these relationships remain unclear. This study aims to identify the factors influencing negative symptoms in schizophrenia and examine their relationship with anxiety and depression to guide more effective interventions and improve patient outcomes.Methods: This study recruited 300 inpatients with schizophrenia from October 2022 to May 2023. Sociodemographic data and clinical characteristics were collected via a self-designed questionnaire. Negative symptoms, depression, and anxiety were assessed using the SANS, HAMD, and HAMA scales, respectively.Results: Multiple regression analysis indicated that familial support (β = − 1.285, P = 0.005), friend support (β = − 0.797, P = 0.032), sleep quality (β = 2.307, P < 0.001), anxiety (β = 0.264, P = 0.004), and depression (β = 0.324, P = 0.007) were the main factors influencing negative symptoms. After adjusting for the duration of psychiatric disorder and type of antipsychotic medication as covariates, the above factors remained primary contributors to negative symptoms.Conclusion: Enhancing familial support, friend support, and addressing emotional health and sleep disturbances are strategies that may alleviate negative symptoms in patients with schizophrenia.Keywords: negative symptoms, anxiety, depression, schizophrenia, mental health |
| format | Article |
| id | doaj-art-5f8030a3aed74e77814a68591f0a1cc9 |
| institution | Kabale University |
| issn | 1178-2021 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Neuropsychiatric Disease and Treatment |
| spelling | doaj-art-5f8030a3aed74e77814a68591f0a1cc92025-02-04T17:15:41ZengDove Medical PressNeuropsychiatric Disease and Treatment1178-20212025-02-01Volume 2122924099849Factors Affecting Negative Symptoms in Schizophrenia and Their Relationship with Anxiety and DepressionZeng GLiang RXiao LCao WZhou WWang WLiu CZhou HShi XChen BChen WGang Zeng,1,2,* Rongyu Liang,2,3,* Lingxian Xiao,2,4,* Weiye Cao,5 Wenqing Zhou,2,6 Wen Wang,5 Cuixia Liu,2,7 Huarong Zhou,1,2 Xiaolei Shi,1,2 Ben Chen,1,2 Wanhua Chen2,4 1Geriatric Neuroscience Center, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of China; 2Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Guangzhou Medical University, Guangzhou, People’s Republic of China; 3Department of Geriatric Psychiatry, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of China; 4Department of Nursing, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of China; 5School of Nursing, Guangzhou Medical University, Guangzhou, People’s Republic of China; 6Adult Psychiatry Department, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of China; 7Chronic Psychiatry Department, The Affiliated Brain Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wenqing Zhou, Adult Psychiatry Department, Affiliated Brain Hospital of Guangzhou Medical University, 36 mingXin Road, Liwan District, Guangzhou, People’s Republic of China, Tel +86 15918636953, Email 996459134@qq.com Weiye Cao, School of Nursing, Guangzhou Medical University, 195 Dongfeng West Road, Yuexiu District, Guangzhou, People’s Republic of China, Tel +86 13149399874, Email 1271932456@qq.comObjective: Negative symptoms significantly impair daily functioning and worsen clinical outcomes. Meanwhile, these symptoms are closely linked to anxiety and depression, further complicating prognosis. The mechanisms underlying these relationships remain unclear. This study aims to identify the factors influencing negative symptoms in schizophrenia and examine their relationship with anxiety and depression to guide more effective interventions and improve patient outcomes.Methods: This study recruited 300 inpatients with schizophrenia from October 2022 to May 2023. Sociodemographic data and clinical characteristics were collected via a self-designed questionnaire. Negative symptoms, depression, and anxiety were assessed using the SANS, HAMD, and HAMA scales, respectively.Results: Multiple regression analysis indicated that familial support (β = − 1.285, P = 0.005), friend support (β = − 0.797, P = 0.032), sleep quality (β = 2.307, P < 0.001), anxiety (β = 0.264, P = 0.004), and depression (β = 0.324, P = 0.007) were the main factors influencing negative symptoms. After adjusting for the duration of psychiatric disorder and type of antipsychotic medication as covariates, the above factors remained primary contributors to negative symptoms.Conclusion: Enhancing familial support, friend support, and addressing emotional health and sleep disturbances are strategies that may alleviate negative symptoms in patients with schizophrenia.Keywords: negative symptoms, anxiety, depression, schizophrenia, mental healthhttps://www.dovepress.com/factors-affecting-negative-symptoms-in-schizophrenia-and-their-relatio-peer-reviewed-fulltext-article-NDTnegative symptomsanxietydepressionschizophreniamental health |
| spellingShingle | Zeng G Liang R Xiao L Cao W Zhou W Wang W Liu C Zhou H Shi X Chen B Chen W Factors Affecting Negative Symptoms in Schizophrenia and Their Relationship with Anxiety and Depression Neuropsychiatric Disease and Treatment negative symptoms anxiety depression schizophrenia mental health |
| title | Factors Affecting Negative Symptoms in Schizophrenia and Their Relationship with Anxiety and Depression |
| title_full | Factors Affecting Negative Symptoms in Schizophrenia and Their Relationship with Anxiety and Depression |
| title_fullStr | Factors Affecting Negative Symptoms in Schizophrenia and Their Relationship with Anxiety and Depression |
| title_full_unstemmed | Factors Affecting Negative Symptoms in Schizophrenia and Their Relationship with Anxiety and Depression |
| title_short | Factors Affecting Negative Symptoms in Schizophrenia and Their Relationship with Anxiety and Depression |
| title_sort | factors affecting negative symptoms in schizophrenia and their relationship with anxiety and depression |
| topic | negative symptoms anxiety depression schizophrenia mental health |
| url | https://www.dovepress.com/factors-affecting-negative-symptoms-in-schizophrenia-and-their-relatio-peer-reviewed-fulltext-article-NDT |
| work_keys_str_mv | AT zengg factorsaffectingnegativesymptomsinschizophreniaandtheirrelationshipwithanxietyanddepression AT liangr factorsaffectingnegativesymptomsinschizophreniaandtheirrelationshipwithanxietyanddepression AT xiaol factorsaffectingnegativesymptomsinschizophreniaandtheirrelationshipwithanxietyanddepression AT caow factorsaffectingnegativesymptomsinschizophreniaandtheirrelationshipwithanxietyanddepression AT zhouw factorsaffectingnegativesymptomsinschizophreniaandtheirrelationshipwithanxietyanddepression AT wangw factorsaffectingnegativesymptomsinschizophreniaandtheirrelationshipwithanxietyanddepression AT liuc factorsaffectingnegativesymptomsinschizophreniaandtheirrelationshipwithanxietyanddepression AT zhouh factorsaffectingnegativesymptomsinschizophreniaandtheirrelationshipwithanxietyanddepression AT shix factorsaffectingnegativesymptomsinschizophreniaandtheirrelationshipwithanxietyanddepression AT chenb factorsaffectingnegativesymptomsinschizophreniaandtheirrelationshipwithanxietyanddepression AT chenw factorsaffectingnegativesymptomsinschizophreniaandtheirrelationshipwithanxietyanddepression |