The effect of fiber supplementation on insulin resistance in children with obesity: a randomized controlled clinical trial
Introduction: Childhood obesity often results in insulin resistance (IR) and may cause type 2 diabetes. Fibers are described as a dietary intervention controlling hyperglycemia; however, their effect on obese children is understudied. Aim: To assess the effect of fiber supplementation on IR in obes...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Hygeia Press di Corridori Marinella
2025-08-01
|
| Series: | Journal of Pediatric and Neonatal Individualized Medicine |
| Subjects: | |
| Online Access: | https://jpnim.com/index.php/jpnim/article/view/1750 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849227294693916672 |
|---|---|
| author | Shrouk Moataz Abdallah Hannah Mohamed Aboulghar Hend Mehawed Abdel Latif Soliman Radwa Marawan Abdel Halim Marwa Ahmed Sedkey |
| author_facet | Shrouk Moataz Abdallah Hannah Mohamed Aboulghar Hend Mehawed Abdel Latif Soliman Radwa Marawan Abdel Halim Marwa Ahmed Sedkey |
| author_sort | Shrouk Moataz Abdallah |
| collection | DOAJ |
| description | Introduction: Childhood obesity often results in insulin resistance (IR) and may cause type 2 diabetes. Fibers are described as a dietary intervention controlling hyperglycemia; however, their effect on obese children is understudied.
Aim: To assess the effect of fiber supplementation on IR in obese children.
Methods: A randomized controlled trial was carried out at Cairo University Children’s Hospital (Cairo, Egypt), including 123 obese children aged 6-13 years. Two-step double blind randomization using sealed envelopes was done. Step 1: randomization into an intervention group (82 subjects) and control group (41 subjects). Step 2: randomization of the intervention group for either receiving 10 g/day of powdered psyllium or a high fiber diet. Fasting insulin, glucose, C-peptide and homeostatic model assessment of IR (HOMA-IR) were measured at baseline and after 8 weeks for all participants.
Results: Fasting glucose, insulin, C-peptide and HOMA-IR were significantly reduced with psyllium (p < 0.001 for all) and natural fibers (p = 0.001, < 0.001, < 0.001 and < 0.001 respectively), while they were increased in the control group (p = 0.09, 0.006, 0.015 and < 0.001 respectively). The median percent of change from baseline for HOMA-IR was -26.47% and -42.55% compared to +9.38% for the natural fiber group, psyllium group and controls respectively. Psyllium induced better HOMA-IR profiles as compared to the other 2 groups (p < 0.001). Both interventions similarly reduced BMI and waist for height z-scores compared to the control group. We report no serious side effects of psyllium; however, unpalatability was a frequent complaint (40.5%).
Conclusion: Both psyllium and natural fibers improved IR in obese children but this improvement was more pronounced in the psyllium group. |
| format | Article |
| id | doaj-art-5f7fbae4b3684d87b34f8db8f0977ddf |
| institution | Kabale University |
| issn | 2281-0692 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Hygeia Press di Corridori Marinella |
| record_format | Article |
| series | Journal of Pediatric and Neonatal Individualized Medicine |
| spelling | doaj-art-5f7fbae4b3684d87b34f8db8f0977ddf2025-08-23T14:56:13ZengHygeia Press di Corridori MarinellaJournal of Pediatric and Neonatal Individualized Medicine2281-06922025-08-01142e140203e14020310.7363/1402031769The effect of fiber supplementation on insulin resistance in children with obesity: a randomized controlled clinical trialShrouk Moataz Abdallah0https://orcid.org/0000-0002-2015-757XHannah Mohamed Aboulghar1https://orcid.org/0000-0002-6527-3638Hend Mehawed Abdel Latif Soliman2https://orcid.org/0000-0003-0225-172XRadwa Marawan Abdel Halim3Marwa Ahmed Sedkey4https://orcid.org/0000-0001-7762-5939Department of Pediatrics, Cairo University, Cairo, EgyptDepartment of Pediatrics, Cairo University, Cairo, EgyptDepartment of Pediatrics, Cairo University, Cairo, EgyptDepartment of Clinical and Chemical Pathology, Cairo University, Cairo, EgyptDepartment of Pediatrics, Cairo University, Cairo, EgyptIntroduction: Childhood obesity often results in insulin resistance (IR) and may cause type 2 diabetes. Fibers are described as a dietary intervention controlling hyperglycemia; however, their effect on obese children is understudied. Aim: To assess the effect of fiber supplementation on IR in obese children. Methods: A randomized controlled trial was carried out at Cairo University Children’s Hospital (Cairo, Egypt), including 123 obese children aged 6-13 years. Two-step double blind randomization using sealed envelopes was done. Step 1: randomization into an intervention group (82 subjects) and control group (41 subjects). Step 2: randomization of the intervention group for either receiving 10 g/day of powdered psyllium or a high fiber diet. Fasting insulin, glucose, C-peptide and homeostatic model assessment of IR (HOMA-IR) were measured at baseline and after 8 weeks for all participants. Results: Fasting glucose, insulin, C-peptide and HOMA-IR were significantly reduced with psyllium (p < 0.001 for all) and natural fibers (p = 0.001, < 0.001, < 0.001 and < 0.001 respectively), while they were increased in the control group (p = 0.09, 0.006, 0.015 and < 0.001 respectively). The median percent of change from baseline for HOMA-IR was -26.47% and -42.55% compared to +9.38% for the natural fiber group, psyllium group and controls respectively. Psyllium induced better HOMA-IR profiles as compared to the other 2 groups (p < 0.001). Both interventions similarly reduced BMI and waist for height z-scores compared to the control group. We report no serious side effects of psyllium; however, unpalatability was a frequent complaint (40.5%). Conclusion: Both psyllium and natural fibers improved IR in obese children but this improvement was more pronounced in the psyllium group.https://jpnim.com/index.php/jpnim/article/view/1750fiberhoma-irinsulin resistanceobesitypsyllium |
| spellingShingle | Shrouk Moataz Abdallah Hannah Mohamed Aboulghar Hend Mehawed Abdel Latif Soliman Radwa Marawan Abdel Halim Marwa Ahmed Sedkey The effect of fiber supplementation on insulin resistance in children with obesity: a randomized controlled clinical trial Journal of Pediatric and Neonatal Individualized Medicine fiber homa-ir insulin resistance obesity psyllium |
| title | The effect of fiber supplementation on insulin resistance in children with obesity: a randomized controlled clinical trial |
| title_full | The effect of fiber supplementation on insulin resistance in children with obesity: a randomized controlled clinical trial |
| title_fullStr | The effect of fiber supplementation on insulin resistance in children with obesity: a randomized controlled clinical trial |
| title_full_unstemmed | The effect of fiber supplementation on insulin resistance in children with obesity: a randomized controlled clinical trial |
| title_short | The effect of fiber supplementation on insulin resistance in children with obesity: a randomized controlled clinical trial |
| title_sort | effect of fiber supplementation on insulin resistance in children with obesity a randomized controlled clinical trial |
| topic | fiber homa-ir insulin resistance obesity psyllium |
| url | https://jpnim.com/index.php/jpnim/article/view/1750 |
| work_keys_str_mv | AT shroukmoatazabdallah theeffectoffibersupplementationoninsulinresistanceinchildrenwithobesityarandomizedcontrolledclinicaltrial AT hannahmohamedaboulghar theeffectoffibersupplementationoninsulinresistanceinchildrenwithobesityarandomizedcontrolledclinicaltrial AT hendmehawedabdellatifsoliman theeffectoffibersupplementationoninsulinresistanceinchildrenwithobesityarandomizedcontrolledclinicaltrial AT radwamarawanabdelhalim theeffectoffibersupplementationoninsulinresistanceinchildrenwithobesityarandomizedcontrolledclinicaltrial AT marwaahmedsedkey theeffectoffibersupplementationoninsulinresistanceinchildrenwithobesityarandomizedcontrolledclinicaltrial AT shroukmoatazabdallah effectoffibersupplementationoninsulinresistanceinchildrenwithobesityarandomizedcontrolledclinicaltrial AT hannahmohamedaboulghar effectoffibersupplementationoninsulinresistanceinchildrenwithobesityarandomizedcontrolledclinicaltrial AT hendmehawedabdellatifsoliman effectoffibersupplementationoninsulinresistanceinchildrenwithobesityarandomizedcontrolledclinicaltrial AT radwamarawanabdelhalim effectoffibersupplementationoninsulinresistanceinchildrenwithobesityarandomizedcontrolledclinicaltrial AT marwaahmedsedkey effectoffibersupplementationoninsulinresistanceinchildrenwithobesityarandomizedcontrolledclinicaltrial |