The role and impact of the IL-6 mediated JAK2-STAT1/3 signaling pathway in the pathogenesis of gout

The role and impact of the IL-6 mediated JAK2-STAT1/3 signaling pathway in the pathogenesis of gout

BackgroundInterleukin-6 (IL-6) is a pleiotropic cytokine, with specific effects depending on the immune microenvironment. Extensive research has confirmed the pathological roles of the IL-6/JAK2/STAT1/3 signaling pathway in inflammation, autoimmunity, and cancer, as well as its involvement in the pa...

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Main Authors: Zeng Zhang, Peng Wang, Tianyi Lei, Jianwei Guo, Yi Jiang, Yanhui Li, Jianxiong Zheng, Shunbing Wang, Haimuzi Xu, Guilin Jian, Quanbo Zhang, Yufeng Qing
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
Subjects:
gout
IL-6
JAK2
STAT1
stat3
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1480844/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1480844/full

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