Globular-shaped Aβ oligomers have diverse mechanisms for promoting Aβ aggregations with the facilitation of fibril elongation

Globular-shaped Aβ oligomers have diverse mechanisms for promoting Aβ aggregations with the facilitation of fibril elongation

The accumulation of amyloid β-proteins (Aβ) in the extracellular space, forming insoluble plaques, is a primary pathological process underlying Alzheimer's disease (AD). Among the various Aβ species that appear during Aβ aggregation, Aβ oligomers are considered the most neurotoxic form. However...

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Bibliographic Details
Main Authors: Hiroto Nakano, Sadao Hikishima, Makoto Mori, Jota Minamikawa, Daiki Muramatsu, Yasuhiro Sakashita, Tokuhei Ikeda, Moeko Noguchi-Shinohara, David B. Teplow, Kenjiro Ono
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Neurobiology of Disease
Subjects:
Alzheimer's disease
Aβ
Globular-shaped Aβ oligomer
High-molecular-weight Aβ oligomer
High-speed atomic force microscopy
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996124003772
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