The Influence of Nanoparticle on Vaccine Responses against Bacterial Infection
Nowadays, nanovaccine is considered as an evolving method in the field of vaccination to induce immunity in the human body against various diseases, including bacterial or viral diseases as well as virulent tumors. Nanovaccines are more efficient than traditional vaccines since they could potentiall...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Journal of Nanotechnology |
| Online Access: | http://dx.doi.org/10.1155/2022/6856982 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832559418229653504 |
|---|---|
| author | Sareh Bagheri-Josheghani Bita Bakhshi Shahin Najar-peerayeh |
| author_facet | Sareh Bagheri-Josheghani Bita Bakhshi Shahin Najar-peerayeh |
| author_sort | Sareh Bagheri-Josheghani |
| collection | DOAJ |
| description | Nowadays, nanovaccine is considered as an evolving method in the field of vaccination to induce immunity in the human body against various diseases, including bacterial or viral diseases as well as virulent tumors. Nanovaccines are more efficient than traditional vaccines since they could potentially induce both humoral and cellular immune reactions. Various studies have shown that nanoparticles with multiple compounds have been designed as delivery systems or as adjuvants for vaccines. Nanoparticles could function as a drug delivery tool, as an adjuvant to promote antigen processing, and as an immune modulator to induce immune responses. These nanoparticles generate immune responses through activating immune cells as well as through the production of antibody responses. Design engineering of nanoparticles (NPs) used to produce nanovaccines to induce immunity in the human body needs comprehensive information about the ways they interact with the component of immune system. Challenges remain due to the lack of sufficient and comprehensive information about the nanoparticles' mode of action. Several studies have described the interactions between various classes of nanoparticles and the immune system in the field of prevention of bacterial infections. The results of some studies conducted in recent years on the interaction between nanoparticles and biosystems have considerably affected the methods used to design nanoparticles for medical applications. In this review, NPs’ characteristics influencing their interplay with the immune system were discussed in vivo. The information obtained could lead to the development of strategies for rationalizing the design of nanovaccines in order to achieve optimum induction of immune response. |
| format | Article |
| id | doaj-art-5f502d93e03946b6a82f68c12cf8cc62 |
| institution | Kabale University |
| issn | 1687-9511 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Nanotechnology |
| spelling | doaj-art-5f502d93e03946b6a82f68c12cf8cc622025-02-03T01:30:04ZengWileyJournal of Nanotechnology1687-95112022-01-01202210.1155/2022/6856982The Influence of Nanoparticle on Vaccine Responses against Bacterial InfectionSareh Bagheri-Josheghani0Bita Bakhshi1Shahin Najar-peerayeh2Department of BacteriologyDepartment of BacteriologyDepartment of BacteriologyNowadays, nanovaccine is considered as an evolving method in the field of vaccination to induce immunity in the human body against various diseases, including bacterial or viral diseases as well as virulent tumors. Nanovaccines are more efficient than traditional vaccines since they could potentially induce both humoral and cellular immune reactions. Various studies have shown that nanoparticles with multiple compounds have been designed as delivery systems or as adjuvants for vaccines. Nanoparticles could function as a drug delivery tool, as an adjuvant to promote antigen processing, and as an immune modulator to induce immune responses. These nanoparticles generate immune responses through activating immune cells as well as through the production of antibody responses. Design engineering of nanoparticles (NPs) used to produce nanovaccines to induce immunity in the human body needs comprehensive information about the ways they interact with the component of immune system. Challenges remain due to the lack of sufficient and comprehensive information about the nanoparticles' mode of action. Several studies have described the interactions between various classes of nanoparticles and the immune system in the field of prevention of bacterial infections. The results of some studies conducted in recent years on the interaction between nanoparticles and biosystems have considerably affected the methods used to design nanoparticles for medical applications. In this review, NPs’ characteristics influencing their interplay with the immune system were discussed in vivo. The information obtained could lead to the development of strategies for rationalizing the design of nanovaccines in order to achieve optimum induction of immune response.http://dx.doi.org/10.1155/2022/6856982 |
| spellingShingle | Sareh Bagheri-Josheghani Bita Bakhshi Shahin Najar-peerayeh The Influence of Nanoparticle on Vaccine Responses against Bacterial Infection Journal of Nanotechnology |
| title | The Influence of Nanoparticle on Vaccine Responses against Bacterial Infection |
| title_full | The Influence of Nanoparticle on Vaccine Responses against Bacterial Infection |
| title_fullStr | The Influence of Nanoparticle on Vaccine Responses against Bacterial Infection |
| title_full_unstemmed | The Influence of Nanoparticle on Vaccine Responses against Bacterial Infection |
| title_short | The Influence of Nanoparticle on Vaccine Responses against Bacterial Infection |
| title_sort | influence of nanoparticle on vaccine responses against bacterial infection |
| url | http://dx.doi.org/10.1155/2022/6856982 |
| work_keys_str_mv | AT sarehbagherijosheghani theinfluenceofnanoparticleonvaccineresponsesagainstbacterialinfection AT bitabakhshi theinfluenceofnanoparticleonvaccineresponsesagainstbacterialinfection AT shahinnajarpeerayeh theinfluenceofnanoparticleonvaccineresponsesagainstbacterialinfection AT sarehbagherijosheghani influenceofnanoparticleonvaccineresponsesagainstbacterialinfection AT bitabakhshi influenceofnanoparticleonvaccineresponsesagainstbacterialinfection AT shahinnajarpeerayeh influenceofnanoparticleonvaccineresponsesagainstbacterialinfection |